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Completed

NCT Number: NCT01792037

Single Dose of Etomidate and Adrenal Cortex

we aim to evaluate the effects of single dose of etomidate or use of steroid prior to etomidate during emergency intubation on hemodynamics and adrenal cortex.

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Key information

Conditions

Adrenocortical Deficiency Hemodynamic Instability

Age range

25 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Cerrahpasa Medical Faculty Anesthesiology and Reanimation Department

Istanbul, Fatih, 34400, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients between 25-65 years old with American Society of Anesthesiology scores III or IV that have applied to emergency department and receives an indication for intubation by the intensive care unit physicians will be included to the study

Exclusion criteria

  • Patients using steroid prior to the intubation and/or patients with chronical inflammatory diseases will be excluded from the study.

Treatment and study plan

Etomidate

Drug

Other names: etomidate lipuro, BRAUN

midazolam

Drug

Other names: Dormicum,Roche

methylprednisolone

Drug

Other names: Prednol-L, Mustafa Nevzat

Primary outcomes

  1. effect of use of steroid on adrenal cortex prior to single dose etomidate by comparing cortisol levels

    Time frame: 24 hours

Secondary outcomes

  1. compare effects of midazolam and etomidate on systemic blood pressure

    Time frame: 24 hours

Sponsors and collaborators

Lead sponsor

Istanbul University

Other

Registry information

Official study title

the Effect of Single Dose of Etomidate Used During Emergency Intubation on Hemodynamics and Adrenal Cortex: a Randomized Clinical Trial

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Feb 15, 2013
Registry last updated
Aug 26, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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