Single Ascending Dose Study to Evaluate Pharmacokinetics and Food-Effect in Healthy Volunteers

Inclusion criteria

• Healthy male or female, non-smoking subjects.
• Willing to use contraception throughout the duration of the study and for 90 days after the study.
• Capable of consent.

Exclusion criteria

Subjects to whom any of the following applies will be excluded from the study:

• Any clinically significant abnormality, infection, exposure to infection, recent live virus vaccination, or abnormal laboratory test results found during medical screening.
• History of alcohol or drug abuse, or a positive urine drug screen or breath alcohol test at screening.
• History of allergic reactions to protein kinase inhibitors, or significant allergic reactions to any drug.
• Positive pregnancy test at screening.
• Clinically significant ECG abnormalities.
• Participation in a clinical research study involving the administration of an investigational or marketed drug or device within 30 days prior to the first dosing, administration of a biological product in the context of a clinical research study within 90 days prior to the first dosing, or concomitant participation in an investigational study involving no drug or device administration.
• Use of medication other than topical products without significant systemic absorption:
• Donation of plasma within 7 days prior to dosing, or significant blood loss within the past 56 days.
• Subject is pregnant, or breast feeding.