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Completed

NCT Number: NCT04164680

Simultaneously PET/MRI in Prolonged DOC Patients

Recently introduced hybrid PET/MR scanners provide the opportunity to measure simultaneously, and in direct spatial correspondence, both metabolic demand and functional activity of the brain, hence capturing complementary information on the brain's physiological state. Here we exploited PET/MR simultaneous imaging to explore the relationship between the metabolic information provided by resting-state fluorodeoxyglucose-PET (FDG-PET) and fMRI (rs-fMRI) in patients with disorders of consciousness.

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Key information

Conditions

Disorder of Consciousness Brain Damage, Chronic Brain Diseases Central Nervous System Diseases Consciousness Disorders FDG-PET Mental Disorders Minimally Conscious State Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurologic Manifestations Pathological Conditions, Signs and Symptoms Persistent Vegetative State Rs-fMRI Signs and Symptoms Unconsciousness

Age range

16 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

International Vegetative State and Consciousness Science Institute, Hangzhou Normal University

Hangzhou, Zhejiang, 3100036, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • DOC patients （acute, subacute or chronic period）: Coma, UWS and MCS.

Exclusion criteria

  • neuromuscular blocking agents or sedative drugs administered within the prior 24 hours；
  • unstable medical condition；
  • mental implant in the brain

Treatment and study plan

Multimodal Neuroimaging

Diagnostic Test

fludeoxyglucose (FDG-)PET/MR imaging

Primary outcomes

  1. resting-state fMRI

    Time frame: Within 7 days

    Use resting-state fMRI to test the functional connectivity

  2. fludeoxyglucose (FDG-)PET

    Time frame: Within 7 days

    UseFDG-PET to test the metabolism.

Sponsors and collaborators

Lead sponsor

Hangzhou Normal University

Other

Registry information

Official study title

Relationship Between Simultaneously Acquired Resting-state Regional Cerebral Glucose Metabolism and Functional MRI in DOC: a PET/MR Hybrid Scanner Study

Important dates

Study start
2018
Primary completion
2021
Study completion
2021
First posted
Nov 15, 2019
Registry last updated
Jul 8, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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