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Completed

NCT Number: NCT06682897

Simplified Tai Chi Exercises to Improve Function in People With Chronic Ankle Instability

The goal of this interventional trial is to evaluate the effectiveness of the simplified four-week Tai Chi training in improving function in people with chronic ankle instability. The main questions it aims to answer are:

1. Does the 4-week Tai Chi training improve ankle neuromuscular responses? 2. Does the 4-week Tai Chi training enhance ankle proprioception? 3. Does the 4-week Tai Chi training improve ankle muscle strength？ 4. Does the 4-week Tai Chi training boost balance performance？ 5. Does the 4-week Tai Chi training enhance subjective ankle stability and quality of life?

Researchers will compare Tai Chi training to self-management to see if this Tai Chi training works to enhance ankle stability performance.

Participants will:

1. Take self-management and Tai Chi training, and each for 4 weeks 2. Visit the labs every 4 weeks for biomechanical measurements and questionnaires, totally 3 times.

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Key information

Conditions

Chronic Ankle Instability

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Loughborough University

Loughborough, Leicester, LE113TU, United Kingdom

About this study

Tai Chi is a traditional Chinese exercise practiced by millions worldwide to stay active and improve health. Based on muscle activation levels across the full set of movements (108 forms), we developed a simplified 16-form Tai Chi routine to enhance ankle stability for individuals with chronic ankle instability.

To evaluate the benefits of this simplified 16-form version for ankle function in people with chronic ankle instability, we are recruiting individuals managing symptoms of chronic ankle instability for a 4-week training program and assess their ankle-related function three times. All participants are randomly allocated to both the Tai Chi training group or a self-management control group, while maintaining their usual lifestyle and exercise routines throughout the study. All participants will complete the same training content and assessment tasks; participants in the control group will be offered the Tai Chi training following completion of the second outcome assessment.

The Tai Chi training includes a total of 12 sessions over 4 weeks, with three sessions per week, each lasting 1 hour (10 minutes of warm-up, 45 minutes of Tai Chi practice, and a 5-minute cool down). Each of the three functional assessments will include consistent measures, including muscle activation, proprioception, muscle strength, balance testing, and self-assessment scales (ankle function and quality of life).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged from 18 to 40
  • A history of at least one significant lateral ankle sprain was associated with inflammatory symptoms (pain, swelling, etc) and disrupted activity
  • The initial sprain must have occurred at least 12 months prior to study enrolment
  • The most recent injury must have occurred more than 3 months prior to study enrolment
  • Reports of feeling instable or "giving way" during daily activities or physical activities and experienced at least 2 episodes in the 6 months prior to study enrolment
  • Scoring ≤25 on the Cumberland Ankle Instability Tool

Exclusion criteria

  • Any previous fractures or surgeries on the lower limbs
  • Have other muscle, joint or nerve disorders that affect the function of the lower limbs
  • Chest pain at rest, dizziness during rest, heart condition, or doctor's advice not to exercise without medical supervision
  • Currently enrolled in other ankle rehabilitation programmes
  • Already a Tai Chi practitioner
  • Pregnant
  • Allergic to adhesive tapes

Treatment and study plan

Tai Chi training

Behavioral

60 minutes each session, three sessions per week, lasting 4 weeks for undertaking.

Primary outcomes

  1. Ankle neuromuscular reponses

    Time frame: From the date of randomization until the completion of three assessments. This evaluation will be conducted at 0, 4, and 8 weeks after enrollment, with a maximum duration of 8 weeks.

    This includes two tasks, one is drop-landing, the other is ankle inversion perturbation. Each side will perform each task three times. Six electromyography muscle sensors will be placed on peroneus longus, peroneus brevis and tibialis anterior muscles to record muscle activity.

Secondary outcomes

  1. Ankle proprioception

    Time frame: From the date of randomization until the completion of three assessments. This evaluation will be conducted at 0, 4, and 8 weeks after enrollment, with a maximum duration of 8 weeks.

    Proprioception will be tested using both the Humac Norm dynamometer and the trapdoor devices.

    Humac: Participants' ankles will be moved to inversion positions of 10 and 20 degrees and eversion positions of 10 and 15 degrees under the Humac device. The degrees of their active and passive replication will be recorded.

    Trapdoor: The tilt angle will be adjusted using four wooden blocks to 10, 12, 14, and 16 degrees. Each angle will be repeated randomly 10 times, totaling 40 trials. The perceived height number for each trial will be recorded.

  2. Ankle muscle strength

    Time frame: From the date of randomization until the completion of three assessments. This evaluation will be conducted at 0, 4, and 8 weeks after enrollment, with a maximum duration of 8 weeks.

    Ankle Muscle Strength will be assessed using the HUMAC Norm dynamometer. The assessment of eversion will be conducted at a speed of 30°/s (eccentric and concentric), and inversion will be conducted at a speed of 60°/s (eccentric and concentric). The peak of the participant's maximum effort three times will be recorded.

  3. Balance performance

    Time frame: From the date of randomization until the completion of three assessments. This evaluation will be conducted at 0, 4, and 8 weeks after enrollment, with a maximum duration of 8 weeks.

    Static balance:

    Participants are asked to complete three trials of unipedal stance on both limbs in both open and close eyes. A total of 12 trials are required, with each trial lasting for 10 s.

    Dynamic balance:

    SEBT: Three times each side. The most distal aspect of the great toe on 0 (crossroad of eight lines) during the entire procedure.The maximum distance (centimeters) for each reach direction is recorded.

    DLBT: Three times each side. All participants start by moving their right leg clockwise and their left leg counterclockwise to each direction. After jumping to an outer target, participants need to return to the center target and stabilise for two seconds, then jump again to an outer target. The total time will be recorded.

  4. Questionnaire

    Time frame: From the date of randomization until the completion of three assessments. This evaluation will be conducted at 0, 4, and 8 weeks after enrollment, with a maximum duration of 8 weeks.

    This includes the assessment of subjective ankle stability using the Cumberland Ankle Instability Tool and the Foot and Ankle Ability Measure questionnaire, as well as the evaluation of quality of life using the SF-12 questionnaire.

Sponsors and collaborators

Lead sponsor

Loughborough University

Other

Registry information

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Nov 12, 2024
Registry last updated
Feb 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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