Simplified Rapid Hydration in Preventing CA-AKI Among Patients With Chronic Kidney Disease

No well-defined protocols exist to guide fluid administration for prevention of contrast-associated acute kidney injury in high risk patients undergoing coronary angiography. Long term hydration at routine speed(12h before and after procedure at 1ml/kg/h), as the most recommended adequate hydration, has been carried out to prevent contrast-associated acute kidney injury in lots of clinical trials. Base on the data in the POSEIDON randomized controlled trial with hemodynamic-guided fluid administration, short term hydration at high speed(1h before and 4h after procedure at 3ml/kg/h) may not be inferior to the classic long term hydration, the speed should be reduced half of the intended speed in all the patients. We hypothesized short term hydration may not be inferior to the long one to reduced significantly the hospital stay and healthy cost.

Inclusion criteria

• ≥18 years of age;
• Written informed consent;
• Candidates scheduled for coronary intervention (angiography and/or coronary intervention);
• Patients with chronic renal insufficiency, the baseline estimated glomerular filtration rate (eGFR) was 15-60 mL/min / 1.73 m²
• At least one risk factor (age>75 years, medical history of diabetes mellitus or hypertension, congestive heart failure [NYHA class >II or history of acute pulmonary edema]);

Exclusion criteria

• End-stage renal failure or heart/renal transplantation;
• History of exposure to contrast medium or acute infectious diseases within 48 hours prior to the procedure;
• Acute decompensated heart failure;
• Left ventricular thrombus;
• Allergy to contrast agent;
• Pregnancy or lactation;
• Malignant tumour or life expectancy <1 year;
• Pre-procedural receipt of NSAIDs (except Asprin), aminoglycosides, cyclosporine or cisplatin in the past 48 h;
• Severe valve disease or elective undergoing surgery.