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Completed

NCT Number: NCT02845388

Sildenafil Citrate in Frozen Embryo Transfer

Comparison between usage of Sildenafil citrate with estradiol valerate or estradiol valerate alone in endometrial preparation and outcome of frozen-thawed embryo transfer cycles.

Completed

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

20 year–37 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 2

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • all cases have at least 2 good quality blastocysts available for transfer

Exclusion criteria

  • uterine structural abnormalities
  • advanced uterine disease
  • hydrosalpinx and pyosalpinx

Treatment and study plan

sildenafil citrate

Drug

Other names: Viagra

estradiol valerate

Drug

Primary outcomes

  1. endometrial pattern

    Time frame: starting from 8th day till 12th day of the menstrual cycle

    Endometrial pattern will be trilaminar or bilaminar after it's preparation with estradiol valerate alone or estradiol valerate and sildenafil citrate. Endometrial pattern will be estimated by transvaginal ultrasonography for trilaminar pattern every other day from 8th day till 12th day of the menstrual cycle.

Secondary outcomes

  1. endometrial thickness

    Time frame: starting from 8th day till 12th day of menstrual cycle

    Endometrial thickness will be estimated by transvaginal ultrasonography after it's preparation with estradiol valerate alone or estradiol valerate and sildenafil citrate for thickness 8 mm or more every other day from 8th day till 12th day of the menstrual cycle.

  2. biochemical pregnancy test

    Time frame: 2 weeks after embryo transfer

    Serum B,human chorionic gonadotropin subunit will be measured 2 weeks after embryo transfer which will be positive when it's level exceeds 5 milli international unit /milli litre in patient's serum.

Sponsors and collaborators

Lead sponsor

Omar Ahmed El Sayed Saad

Other

Registry information

Official study title

Sildenafil Citrate for Endometrial Preparation in Frozen-thawed Embryo Transfer Cycles

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Jul 27, 2016
Registry last updated
Jul 27, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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