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Completed

NCT Number: NCT02902614

Side of Embryo Biopsy Interfering Implantation Potential

Selection of side of embryo biopsy that will not interfering with implantation power of developed blastocyst embryo during biopsy procedure arranged for PGT.

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Key information

Conditions

Preimplantation Diagnosis

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

AHMAD Barakat, Manama, Bahrain

Loading trial locations.

About this study

During process of embryo biopsy, it was indicated to avoid contacting cells closer to inner cell mass as it can decrease the quality of embryo and its structural composition. However, recommendation for collection from the trophectoderm (TE) side is indicated.

Absence of differentiation during cleavage-stage or morula stage at day 3 and day 4 respectively, will present the needful to focus a specific location for embryo biopsy during pre-blastocyst stages for embryo going to do genetic testing before implantation or embryo transfer.

In articulation around the second polar body or the animal pole of embryo, collection of the cell from the vegetal pole in crospondence to avoide collection form the animal pole is to be compare the results of implantation for biopsy done using the animal pole side or the random non organized biosy procedure.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • grade 1 or 2 embryos at eight cell stage or 8-1/ 8-2 embryo quality.

Exclusion criteria

  • grade 3 embryo at day 3, or 8-3 embryos.

Treatment and study plan

Vegetal Pole blastomer embryo

Procedure

for day 3 embryo biopsy / cleavage stage

Other names: Biopsy embryo from sides considered far from ICM location.

Animal Pole blastomer embryo

Procedure

for day 3 embryo biopsy / cleavage stage

Other names: Random biopsy without considering specific location

Primary outcomes

  1. blastocyst location of ICM at day 5

    Time frame: 2 months

    describing the location of the inner cell mass (ICM) in location to the zona peluceda (ZP) drilling opening.

Secondary outcomes

  1. Implantation power

    Time frame: 2 months

    calculating the pregnancy rate for cases after biopsy.

Sponsors and collaborators

Lead sponsor

Ahmad Mustafa Mohamed Metwalley

Other

Collaborators

  • Ibn Sina Hospital

Registry information

Official study title

Effect of Embryo Biopsy Side on Post Biopsy Blastocyst Structurs and Implantation

Important dates

Study start
2015
Primary completion
2018
Study completion
2018
First posted
Sep 16, 2016
Registry last updated
Jan 15, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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