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Completed

NCT Number: NCT04141072

Shrunken Pore Syndrome: a Retrospective, Single Center, Cohort Study

To study the impact a difference in renal clearance of small and large molecules has on long-term survival.

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Key information

Conditions

Kidney Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Male Urogenital Diseases Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Skåne University Hospital

Lund, Skåne County, 22241, Sweden

About this study

Renal dysfunction is considered a major risk factor in cardiac surgery. Renal function has earlier been estimated by creatinine and more recently by cystatin C, both of which are analysed in a blood sample. New evidence seems to suggest that if the ratio between estimated renal function from cystatin C and creatinine is below 60% the patient has a higher rate of mortality irrespective of renal function. This syndrome is named Shrunken Pore Syndrome.

We study patients whom have undergone elective cardiac surgery at our institution and on whom we before the surgery has collected blood samples. They are all included in our in house patient registry and qulaity database and afterwards we match this data to our national tax registry to get data on mortality.

Our aim is to evaluate whether Shrunken Pore Syndrome influence mortality following elective cardiac surgery.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Elective CABG and/or sAVR at the department of Cardiothoracic Surgery, Skåne University Hospital in Lund, Sweden between 1 January 2010 and 31 December 2015.

Exclusion criteria

  • Emergency operation
  • Redo operation
  • Preoperatively missing cystatin C or creatinine

Treatment and study plan

Shrunken Pore Syndrome

Diagnostic Test

eGFR Cystatin C ≤ 60% of eGFR Creatinine

Primary outcomes

  1. Mortality during follow up

    Time frame: 1 January 2010 - 1 January 2019

    All cause mortality at follow up

Sponsors and collaborators

Lead sponsor

Henrik Bjursten

Other

Registry information

Official study title

Shrunken Pore Syndrome's Effect on Mortality in Elective Cardiac Surgery

Important dates

Study start
2010
Primary completion
2015
Study completion
2019
First posted
Oct 28, 2019
Registry last updated
Sep 21, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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