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Completed

NCT Number: NCT02168166

Short-term Working Memory and Executive Training

Cognitive remediation (CR) therapies refer to a number of recent developments to use behavioural strategies to improve neurocognitive abilities and improve everyday functioning in mental disorders such as schizophrenia, bipolar disorder, and depression. In this study, we aim to examine whether we can observe CR effects on measures of neuroplasticity, cognition, and functioning when using a rigorous control comparison group. We hypothesize that the active group will exhibit improvements in executive functioning composite scores, improved EEG theta-gamma frequency modulation, and increased EEG alpha power compared to the placebo group.

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Key information

Conditions

Psychotic Disorders Mental Disorders Nervous System Diseases Schizophrenia Spectrum and Other Psychotic Disorders

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Queen's University

Kingston, Ontario, K7L3N6, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diagnosis of a chronic mental disorder (defined herein as bipolar disorder, major depressive disorder, or a schizophrenia-spectrum disorder)
  • between the ages of 18 and 65
  • speak and read fluent English
  • able to use a computer

Exclusion criteria

  • active substance abuse or dependence diagnosis
  • sensory or motor issues that would preclude completion of study procedures
  • enrollment in a cognitive remediation program or use of cognitive training programs (e.g. lumosity.com) within the past 6 months

Treatment and study plan

Executive Function Training

Behavioral

Placebo

Behavioral

Placebo version of executive function training

Primary outcomes

  1. Change from baseline executive functioning composite score at post-treatment assessment

    Time frame: Pre-training assessment (Week 1) and post-training assessment (Week 4)

    Composite score based on four tests of cognition

Secondary outcomes

  1. Change from baseline EEG theta-gamma frequency modulation at post-treatment assessment

    Time frame: Pre-training assessment (Week 1) and post-training assessment (Week 4)

    Predicted to improve in active CR (cognitive remediation) condition compared to placebo CR

  2. Change from baseline EEG alpha power at post-treatment assessment

    Time frame: Pre-training assessment (Week 1) and post-training assessment (Week 4)

    Predicted to increase in active CR (cognitive remediation) condition compared to placebo CR

Sponsors and collaborators

Lead sponsor

Queen's University

Other

Registry information

Official study title

Short-Term Executive Functioning Training

Acronym: STExFx

Important dates

Study start
2014
Primary completion
2017
Study completion
2017
First posted
Jun 20, 2014
Registry last updated
Apr 4, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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