Princeton Consumer Research
Raritan, New Jersey, 08869, United States
Completed
NCT Number: NCT07521059
Short-Term Safety of Low-Dose Creatine Hydrochloride: A 28-Day Single-Arm Pilot Study
Background: Creatine monohydrate (typically 5-20 g/day) has a well-established safety profile across diverse populations. Creatine hydrochloride (CR-HCl) is a highly soluble creatine formulation that may allow effective supplementation at substantially lower doses (750 mg - 3 g/day); however, controlled human safety data specific to CR-HCl remain limited.
Objective: To evaluate the short-term laboratory safety and tolerability of low-dose CR-HCl supplementation administered for 28 days in healthy adults.
Completed
Looking for future studies?
Notify MeKey information
Age range
18 year–60 year
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Primary location
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- healthy adults
Exclusion criteria
- consumed creatine supplements in last 30 days significant medical conditions that could affect outcomes (e.g., diabetes)
Treatment and study plan
creatine supplementation
Dietary Supplement750 mg/day dosing
Primary outcomes
-
No adverse events
Time frame: over 28 days
Sponsors and collaborators
Lead sponsor
Vireo Systems, Inc.
Industry
Registry information
Important dates
- Study start
- 2024
- Primary completion
- 2024
- Study completion
- 2024
- First posted
- Apr 9, 2026
- Registry last updated
- Apr 9, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.