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Completed

NCT Number: NCT03788330

Short-term Health Benefits of Using Fresh Air Filtration System in Classroom

A randomized crossover trial will be conducted in 90 primary school children in 3 classrooms in Shanghai, China. The effects of fresh air ventilation/filtration system, fresh air ventilation system with no filtration and natual ventilation will be compared on the effects of reducing indoor PM2.5 and chilhood health. Biological samples of children are going to be collected to investigate the associations between indoor air pollution and biomarkes of certain health effects.

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Key information

Conditions

Airway Morbidity Cognition Disorders Cognitive and Attention Disorders and Disturbances Disorders of Environmental Origin Environmental Illness Hypersensitivity Immune System Diseases Mental Disorders Neurocognitive Disorders Oxidative Stress Sick Building Syndrome

Age range

10 year–13 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Fudan University

Shanghai, 200032, China

About this study

A randomized crossover trial among 90 primary students in 3 classrooms in Shanghai, China will be performed. Three arms are going to be 1) fresh air filtration system, 2) fresh air system with no filtration and 3) natural ventilation. Each arm is going to be in use for five continuous weekdays followed by one week of wash-out. After one-week of wash out, a cross over change between 3 arms is going to be taked. Then the 2nd week of intervention is performed followed by the 2nd wash-out week. The same cross-over change between 3 arms is going to be repeated again until each classroom will be applied by all three arms of ventilation. A total of 5 weeks is required for the project. Children's biological samples including saliva, urine and skin samples will be collected as well as exhaled NO. A questionnaire on children's perception on air quality will be assessed as well.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All invited primary school children in Grade 5 in an artibrarily selected school

Exclusion criteria

  • Current airway symptoms (cough, airway infection, asthma et al.)
  • Acute infectious diseases

Treatment and study plan

Fresh air system with filtration

Device

Using fresh air ventilation combined with PM2.5 filtration system to reduce the indoor PM2.5 concentration in primarty school classrooms

Other names: mechanical ventilation and filtration system

Primary outcomes

  1. Exhaled nitric oxide

    Time frame: within 2 hours of the end of intervention in each week

    Airway inflammation biomarker

  2. Oxidative stress biomarkers

    Time frame: within 2 hours of the end of intervention in each week

    The level of lysozyme, cortisone and SIgA will be assessed in saliva and other oxidative biomarkers in the urine samples in children.

  3. Sick building symdrom

    Time frame: within 2 hours of the end of intervention in each week

    Answering questionnaire on sick biulding symdrom

Sponsors and collaborators

Lead sponsor

Fudan University

Other

Registry information

Official study title

Effects of Fresh Air Filtration System on Indoor Air Quality and Children's Health in Shanghai Schools

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Dec 27, 2018
Registry last updated
Mar 29, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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