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Completed

NCT Number: NCT01165073

Short Term Feeding for Asian Patients With Liver Cirrhosis

The benefits of short-term naso-gastric feeding in patients with advanced cirrhosis remain uncertain. This was a randomised study comparing naso-gastric feeding and oral feeding in Asian patients with cirrhosis who were admitted to hospital for decompensation.

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Key information

Conditions

Cirrhosis Fibrosis Malnutrition Nutrition Disorders Nutritional and Metabolic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Malaya Medical Centre

Kuala Lumpur, 59100, Malaysia

About this study

Consecutive patients with decompensated cirrhosis who fitted the inclusion criteria, will be randomised to either naso-gastric or oral feeding. Total feeding will be for 2 weeks only. Following intervention specific nutritional and liver-related parameters will be measured during the 2 weeks and up to 6 weeks later. Comparison between both groups will then be made.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with decompensated cirrhosis of any etiology.

Exclusion criteria

  • Advanced hepatic encephalopathy,
  • Variceal bleeding,
  • Hepatocellular carcinoma.

Treatment and study plan

Osmolite and B.C.A.A.

Dietary Supplement

Feeding inserted into enteral tubes

Other names: Enteral supplementation

Normal oral intake & supplementation if necessary

Dietary Supplement

Enteral nutrition

Other names: Enteral supplementation

Primary outcomes

  1. Improvement in Child-Pugh score

    Time frame: Up to 6 weeks

    Change in the Child-Pugh score, assessing liver damage in cirrhosis

Secondary outcomes

  1. Improvement in nutritional parameters

    Time frame: up to 6 weeks

    Improvement in nutritional anthropometry and assessment tool markers after intervention

Sponsors and collaborators

Lead sponsor

University of Malaya

Other

Registry information

Official study title

Short Term Feeding for Hospitalised Asian Patients With Liver Cirrhosis - a Randomised Trial of Naso-gastric vs Oral Feeding

Important dates

Study start
2008
Primary completion
2009
Study completion
2010
First posted
Jul 19, 2010
Registry last updated
Mar 1, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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