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Completed

NCT Number: NCT03503084

Short-term Effects of Tai Chi Chuan Exercise on the Regulation of Lipid and Glucose Metabolisms and Endothelial Function

The short term effects of TCC exercise are the significant increase in serum insulin and insulin resistance, and the significant decrease in serum TC, HDL-C, ET-1 and insulin sensitivity in TCC practitioners. TCC might be benefit the health of its practitioners through the regulation of lipid and glucose metabolism and endothelial function.

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Key information

Conditions

Physiological Effect of TCC on Glucose Metabolism Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Nutritional and Metabolic Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Wan-An Lu

Yilan, Taiwan

About this study

Tai Chi Chuan (TCC) has been shown to be beneficial to the health. However, its effects on lipid and glucose metabolism are not fully understood. This study investigated the short term effect of TCC exercise on lipid and glucose metabolism and endothelial function in TCC practitioners. Twenty-one TCC practitioners and nineteen normal controls were included in this study. The hemodynamics, serum insulin, indices of insulin resistance/sensitivity, serum endothelin-1 (ET-1), blood lipids and aldosterone before and 30 min after a rest or a session of classical Yang's TCC exercise were compared.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • TCC practitioners in a TCC training center in Taiwan over 50 years of age
  • Healthy subjects without TCC experience over 50 years of age

Exclusion criteria

  • Subjects who had major cardiopulmonary disease
  • Subjects who have diabetes mellitus, renal or liver disease

Treatment and study plan

Classical Yang's TCC exercise

Behavioral

Primary outcomes

  1. change in quantitative insulin sensitivity check index

    Time frame: before and 30 minutes after the completion of TCC exercise

    change in insulin sensitivity due to TCC

Secondary outcomes

  1. change in serum total cholesterol

    Time frame: before and 30 minutes after the completion of TCC exercise

    change in serum total cholesterol due to TCC

  2. change in homeostasis model assessment-estimated insulin resistance

    Time frame: before and 30 minutes after the completion of TCC exercise

    change in insulin resistance by TCC

Other outcomes

  1. change in serum triglyceride

    Time frame: before and 30 minutes after the completion of TCC exercise

    change in serum level of triglyceride due to TCC

  2. change in serum low density lipoprotein

    Time frame: before and 30 minutes after the completion of TCC exercise

    change in serum level of low density lipoprotein due to TCC

  3. change in serum high density lipoprotein

    Time frame: before and 30 minutes after the completion of TCC exercise

    change in serum level of high density lipoprotein due to TCC

  4. change in serum insulin

    Time frame: before and 30 minutes after the completion of TCC exercise

    change in serum level of insulin due to TCC

  5. change in serum endothelin-1

    Time frame: before and 30 minutes after the completion of TCC exercise

    change in serum level of endothelin-1 due to TCC

  6. change in serum aldosterone

    Time frame: before and 30 minutes after the completion of TCC exercise

    change in serum level of aldosterone due to TCC

Sponsors and collaborators

Lead sponsor

Changhua Christian Hospital

Other

Collaborators

  • Taipei Veterans General Hospital, Taiwan

Registry information

Official study title

The Effect of Tai Chi Chuan on the Endothelin, Insulin, Blood Lipid, Blood Sugar, Aldosterone and Hemodynamics in the Elderly Adults

Important dates

Study start
2009
Primary completion
2009
Study completion
2009
First posted
Apr 19, 2018
Registry last updated
Apr 19, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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