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Completed

NCT Number: NCT07709026

Short-Term Effects of Intra-Articular Corticosteroid Injection on Knee Function in Juvenile Idiopathic Arthritis

The purpose of this study is to evaluate the short-term clinical effects of intra-articular corticosteroid injections on knee joint functions in children and adolescents diagnosed with Juvenile Idiopathic Arthritis (JIA).

Patients who receive a corticosteroid injection into the knee joint as part of their routine medical treatment will be monitored prospectively. The study aims to assess changes in range of motion, functional status, and pain levels before the injection and during the early follow-up period after the procedure. This will help healthcare providers better understand the immediate benefits and functional outcomes of this treatment in youth sports and daily physical activities.

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Key information

Conditions

Juvenile Idiopathic Arthritis (JIA) Arthritis Arthritis, Juvenile Autoimmune Diseases Connective Tissue Diseases Immune System Diseases Joint Diseases Musculoskeletal Diseases Rheumatic Diseases Skin and Connective Tissue Diseases

Age range

8 year–16 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Necmettin Erbakan University, Faculty of Health Sciences

Konya, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients diagnosed with juvenile idiopathic arthritis (JIA) according to standard criteria (arthritis with onset before the age of 16 years and duration longer than 6 weeks with no other identifiable cause).
  • Having unilateral or bilateral active knee joint arthritis.
  • Undergoing knee intra-articular corticosteroid injection (IACI) for the active knee joint involvement.
  • Provision of written informed consent by both patients and their caregivers.

Exclusion criteria

  • Presence of other chronic rheumatological diseases.
  • Initiation or discontinuation of systemic steroids, conventional disease-modifying anti-rheumatic drugs (DMARDs) (e.g., methotrexate, sulfasalazine), or biologic DMARDs (e.g., inhibitors of TNF, IL-1, or IL-6) within the 3 months before knee IACI and during the follow-up period.
  • History of severe adverse reactions to steroids.
  • Presence of neurological diseases.
  • History of lower extremity surgery.
  • Missing data.

Treatment and study plan

Intra-articular corticosteroid injection

Drug

Patients diagnosed with juvenile idiopathic arthritis (JIA) underwent a routine clinical knee intra-articular corticosteroid injection (IACI) due to active knee involvement. Clinical, functional, and physical strength assessments were performed prospectively at three specific time points: before the injection (baseline, T0), at 2 weeks post-treatment (T1), and at 2 months post-treatment (T2) to evaluate short-term outcomes.

Primary outcomes

  1. Change from Baseline in Pain Intensity

    Time frame: Baseline (T0), 2 weeks (T1), and 2 months (T2) post-injection

    Pain intensity assessed at rest and during physical activity using a standard assessment scale.

Sponsors and collaborators

Lead sponsor

Necmettin Erbakan University

Other

Registry information

Official study title

Short-Term Effects of Intra-Articular Corticosteroid Injection on Knee Function in Juvenile Idiopathic Arthritis: A Prospective Cohort Study

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Jul 16, 2026
Registry last updated
Jul 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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