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NCT Number: NCT01427231

Short-term Effect of Glucose and Sacharose Ingestion on Cognitive Performance and Mood in Elderly

The objective of the current study is to determine the acute effect of a glucose drink and a sacharose drink compared to a placebo on cognitive performance in elderly with light memory complaints. The investigators expect that the sugar containing drinks will improve memory and attentional functions. Furthermore, blood glucose response will be measured.

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Key information

Conditions

Mental Health Attention Behavior Cognition Memory Personal Satisfaction Psychological Well-Being

Age range

70 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Wageningen University

Wageningen, Gelderland, 6703 HD, Netherlands

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men and women
  • 70 years and older
  • Memory complaints

Exclusion criteria

  • Type I or II diabetes
  • Parkinson disease
  • MMSE < 25 (to exclude cognitively impaired subjects
  • CES-D > 16 (to exclude depressive subjects)
  • Pharmacological antidepressives or medication for dementia
  • Liver disease

Treatment and study plan

Glucose

Dietary Supplement

The effect of a glucose solution on cognitive performance will be measured.

Other names: Sucrose, sugar.

sacharose

Dietary Supplement

The effect of a sacharose solution on cognitive performance will be measured.

Placebo

Dietary Supplement

The effect of a placebo drink with sweeteners on cognitive performance will be measured.

Primary outcomes

  1. Performance on the paired associate recall test

    Time frame: cognitive tests will start 15 minutes after ingestion of the intervention product

    Cognitive performance will be assessed by several sensitive tests. Power is calculated on the paired associate recall test, but also several other cognitive performance test focusing on memory, attention and reaction time will be performed

Secondary outcomes

  1. Mood

    Time frame: within 15 minutes after consuming the test drink and after completing the cognitive tests (within 90 minutes after consuming the test drink)

    Mood will be measured by the POMS, after consuming the test drink, and after completing the congitive tests.

  2. Blood glucose response

    Time frame: from baseline till 90 minutes after consuming the drink

    Blood glucose will be measured at five time points, at t=0, after 15 minutes, 30, 60 and 90 minutes.

  3. Plasma insulin levels

    Time frame: At t= -15 minutes, before consuming the test drink

    One venapunction will be carried out at baseline to measure plasma insulin levels.

Sponsors and collaborators

Lead sponsor

Wageningen University

Other

Collaborators

  • Suikerstichting Nederland (Baarn)

Registry information

Official study title

The Short-term Effect of Glucose and Sacharose Ingestion on Cognitive Performance and Mood in Elderly Subjects

Important dates

Study start
2011
Primary completion
2011
Study completion
2011
First posted
Sep 1, 2011
Registry last updated
Mar 21, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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