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NCT Number: NCT07683611

Short-Axis Versus Long-Axis Ultrasound-Guided Peripheral IV Cannulation in Adults

This randomized study compared two ultrasound-guided techniques for placing a peripheral intravenous cannula in adults aged 20 to 60 years who required intravenous access. Participants were assigned equally to either the short-axis out-of-plane approach or the long-axis in-plane approach. The study evaluated whether the techniques differed in successful cannulation. It also compared cannulation time, number of attempts, and immediate complications, including arterial puncture, extravasation, and haematoma.

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Key information

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Medical Teaching Institution-Lady Reading Hospital

Peshawar, Khyber Pakhtunkhwa, Pakistan

About this study

This single-centre, parallel-group randomized controlled trial was conducted in the Department of Anaesthesiology at Medical Teaching Institution-Lady Reading Hospital, Peshawar, Pakistan.

A total of 222 eligible adults requiring peripheral intravenous access were enrolled through consecutive sampling. Participants were randomized in a 1:1 ratio using a computer-generated sequence. In the short-axis group, the ultrasound probe was positioned perpendicular to the target vein to obtain a transverse image, and the needle was advanced using an out-of-plane technique. In the long-axis group, the probe was positioned parallel to the vein to obtain a longitudinal image, and the needle was advanced in plane while maintaining visualization of the needle tip. Experienced anaesthesiologists performed all procedures.

Cannulation was considered successful when the catheter advanced without resistance, blood returned freely into the hub, and saline could be flushed without local swelling. The primary outcome was successful peripheral intravenous cannulation. Secondary outcomes included cannulation time, number of attempts, and immediate complications comprising arterial puncture, extravasation, and haematoma. No delayed follow-up outcomes were assessed.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men and women aged 20 to 60 years
  • Required peripheral intravenous access

Exclusion criteria

  • Body mass index of 30 kg/m² or greater
  • Infection at the intended cannulation site
  • Upper-limb deformity
  • Previous venous thrombosis
  • Refusal to participate

Treatment and study plan

Short-Axis Out-of-Plane Ultrasound-Guided Cannulation

Procedure

The ultrasound probe was positioned perpendicular to the target vein to obtain a transverse image. A peripheral intravenous cannula was inserted by advancing the needle using the out-of-plane technique under real-time ultrasound guidance.

Long-Axis In-Plane Ultrasound-Guided Cannulation

Procedure

The ultrasound probe was positioned parallel to the target vein to obtain a longitudinal image. A peripheral intravenous cannula was inserted by advancing the needle in plane while maintaining visualization of the needle tip under real-time ultrasound guidance.

Primary outcomes

  1. Successful Peripheral Intravenous Cannulation

    Time frame: Immediately following the assigned cannulation procedure

    Cannulation was considered successful when the catheter advanced without resistance, blood returned freely into the hub, and saline could be flushed without local swelling. The outcome was recorded as successful or unsuccessful.

Secondary outcomes

  1. Cannulation Time

    Time frame: uring the assigned cannulation procedure

    Time required to achieve successful peripheral intravenous cannulation, measured in seconds.

Sponsors and collaborators

Lead sponsor

Lady Reading Hospital, Pakistan

Other Gov

Registry information

Official study title

Comparison of Short-Axis Versus Long-Axis Approach for Ultrasound-Guided Peripheral Intravenous Cannulation: A Randomized Controlled Trial

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Jul 6, 2026
Registry last updated
Jul 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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