Skip to main content
OpenTrials
Completed

NCT Number: NCT04731350

Shock Wave Versus Iontophoresis in Treatment of Subjects With Knee Osteoarthritis

Both extra corporeal shock wave and dexamethasone iontophoresisare effective in treatment of knee osteoarthritis but which one is more effective is not clear yet . so the purpose of this study was to investigate and compare between the effect of shock wave and iontophoresis in treatment of knee osteoarthritis . it was hypothesized that there will be no difference between the effect of shock wave and iontophoresis on treatment of knee osteoarthritis.

Completed

Looking for future studies?

Notify Me

Key information

Age range

40 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of physical therapy ,Cairo University

Giza, 002, Egypt

About this study

60 subjects with grade II knee osteoarthritis will be recruited from outpatient clinic of faculty of physical therapy and then they will be assigned randomly by sealed envelope into three groups ;group A (shock wave group) will received radial extracorporeal shock wave ,group B (Iontophoresis group ) will receive deaxamthasone iontophoresis and group c (control group) will receive traditional tratment ( stregnthening exerciseces) all treatment will be once session per week for four weeks .pain intensity ,knee ROM and knee injury and osteoarthritis outcome score physical function short (KOOS-PS).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Symptomatic knee OA for at least 3 months according to clinical criteria of American College of Rheumatology
  • Radiologic findings had to be compatible with knee OA, with kelgren and Lawrence (K-L) grade 2 in a simple X ray .
  • Tenderness on medial tibial plateau
  • Intensity of pain: visual analogue scale equal to 5 or greater
  • Failure of two or more types of previous conservative treatment (medication, anti-inflammatory drugs, physical therapy, stretching, acupuncture, orthotics and others)

Exclusion criteria

  • Neuorological and vestibular system disorder, systematic inflammatory disease, steroid injections in the last six months
  • Any contraindication to magnetic resonance imaging or radiography, or trauma history on knee
  • history of previous knee surgery -

Treatment and study plan

Radial extracorporeal shock wave

Device

Radial shock wave device, Swiss DolorClast (EMS Electro Medical Systems, Nyon, Switzerland)

Iontophoresis

Device

Iontophoretic drug delivery system (phoresors II auto model PM850 IOMED):

Exercise

Other

strengthening exercise

Primary outcomes

  1. visual analogue scale (VAS)

    Time frame: change from baseline to immediately pre treatment and from pre treatment to immediately post treatment

    pain intensity will be assessed by using visual analogue scale

Secondary outcomes

  1. knee range of motion (ROM)

    Time frame: change from baseline to immediately pre treatment and from pre treatment to immediately post treatment

    electronic geniometer

  2. knee injury and osteoarthritis outcome score physical function short (KOOS-PS)

    Time frame: change from baseline to immediately pre treatment and from pre treatment to immediately post treatment

    knee function by using KOOS-PS questionnaire

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Effect of Extra Corporeal Shock Wave Versus Dexamethasone Iontophoresis in Treatment of Knee Osteoarthritis

Acronym: Shockwave

Important dates

Study start
2021
Primary completion
2022
Study completion
2023
First posted
Jan 29, 2021
Registry last updated
Mar 7, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.