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Completed

NCT Number: NCT02909764

Shifting Salty Taste Preferences in Children

The goals of the proposed research are to determine whether repeated exposure to a low sodium food will result in reduced preference for salt in that food among children; and to determine whether such reductions in preference are related to dietary intake of salt, taste receptor genotype, and anthropometric and physiological measures.

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Key information

Conditions

Age range

7 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Monell Chemical Senses Center

Philadelphia, Pennsylvania, 19104, United States

About this study

This is a within- and between-subjects randomized controlled trial on children consuming either a low sodium or a higher sodium cereal over a 2-month period to determine if repeated exposure to the low sodium cereal is effective for reducing preference for salt in that food. Children will be genotyped for markers related to taste, dietary intake will be recorded, and anthropometric and physiological measures will be collected at baseline.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy
  • Willingness to consume no other cereals during intervention

Exclusion criteria

  • Allergies and/or taking medication that affects taste

Treatment and study plan

Low Sodium Group

Other

Breakfast Cereal

Primary outcomes

  1. Most Preferred Level of Salt Taste

    Time frame: Baseline (time 0) and after 8-week intervention

    Children were presented with pairs of broths with varying concentrations of added salt (0.16, 0.24, 0.38, 0.61, 1.05 M) (17) . The first pair of broths (0.24 and 0.61 M salt) presented were from the middle range of concentrations. Children were instructed to taste each sample within a pair for 5 seconds, to rinse between tastings, and then to point to the sample they liked better. Each subsequent pair of samples contained the concentration selected by the participant paired with an adjacent stimulus concentration. This pattern continued until the child either chose the same concentration when paired with both a lower and higher concentration in two consecutive pairs or chose either the highest or the lowest concentration twice consecutively. The entire task was repeated a, with stimulus pairs presented in reverse order. The geometric mean of the two concentrations chosen in the first and second series was calculated to determine most preferred levels of salt.

  2. Relative Preference for Regular vs Low Sodium Cereal

    Time frame: At baseline and after 8-week intervention

    The number of children who preferred the taste of the low salt cereal when compared to the regular sodium cereal

Secondary outcomes

  1. Salt Taste Detection Thresholds

    Time frame: Baseline and after 8-week intervention

    Detection thresholds (the lowest level of salt detect by taste) were measured via a two-alternative forced-choice procedure

  2. Most Preferred Level of Sucrose

    Time frame: At baseline and after 8-week intervention

    Children were presented with pairs of sucrose solutions of varying concentrations (0.09, 0.18, 0.35, 0.70, 1.05 M). The first pair presented were from the middle range of concentrations. Children tasted each sample and then pointed to the sample they liked better. Each subsequent pair of samples presented contained the concentration selected by the child paired with an adjacent stimulus concentration. This pattern continued until the child either chose the same concentration when paired with both a lower and higher concentration in two consecutive pairs or chose either the highest or the lowest concentration twice consecutively. The entire task was repeated after a 3-minute break, with stimulus pairs presented in reverse order. The geometric mean of the two concentrations chosen in the first and second series was calculated to determine the most preferred levels of sucrose.

  3. Intake of Cereal During Intervention Period

    Time frame: 28 days

    Mothers recorded the amount of cereal their children ingested during 28 days of the 8-week, at-home intervention period.

  4. Blood Pressure

    Time frame: Baseline

    Blood pressure (mmHg) was measured by using an automatic blood pressure machine with pediatric cuff. Blood pressure will be measured at baseline (time 0). There were no a priori hypothesis but were collected as baseline characteristic to ensure no differences between the groups.

Sponsors and collaborators

Lead sponsor

Monell Chemical Senses Center

Other

Registry information

Official study title

Salty Taste: Assessing a Strategy to Reduce Children's Preference

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Sep 21, 2016
Registry last updated
Sep 30, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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