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NCT Number: NCT04404114

Shear Wave Elastography in Differentiating Acute or Chronic Kidney Disease

Chronic kidney disease is a common global public health issue and its prevalence increased year by year. Early diagnosis and intervention can prevent further complications and comorbidities of long-term dialysis, cardiovascular events and mortality as well as improve the patients' life quality. To differentiate acute from chronic kidney disease was crucial especially in the setting of crowded and high-risk emergency department. To diagnose acute or chronic kidney disease, physicians usually use blood sample test combined with image studies such as conventional sonography, CT and MRI. However, there was lots of limited factors. The patients may have no previous visit records, poor renal function to receive contrast medium, or critical clinical condition to undergo time-wasting exam. Although the conventional renal sonography is accessible and inexpensive, the judgement is subjective and provide little clinical information. Recent researches of shear wave elastography in evaluating renal parenchymal stiffness showed some correlation with nephropathy. In our study, aiming to facilitating clinical implication, the investigators will use swear-wave elastography combined with conventional renal sonography to benefit patients in diagnosis of acute or chronic kidney disease.

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Key information

Age range

20 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

National Taiwan University Hospital

Taipei, 100, Taiwan

Location status: Recruiting

Location contact

An-bu Lee, MD.

SUB_INVESTIGATOR

Jia-Yu Chen, MD.

CONTACT

[email protected]

Jia-Yu Chen, MD.

SUB_INVESTIGATOR

Wan-Ching Lien, MD., PhD

CONTACT

[email protected]

+886-2-23123456 ext. 65637

About this study

This is a case-control study. The investigators obtained data from participants who were older than 20 years old and received renal sonography examination in the emergency department of National Taiwan University Hospital. The investigators examined the participants' kidneys by recording the kidney size, cortical thickness, possible lesions and elasticity by shear-wave elastography. These data combined with the participants' medical history and renal function revealed by blood examination will be analyzed. This study was designed to determine the correlation between renal cortical elasticity and chronic kidney disease.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The patients older than 20 years old who needed to receive renal sonography in emergency department of National Taiwan University Hospital.

Exclusion criteria

  • The patients who didn't obtain agreement.
  • The patients who can't cooperate or follow the directions

Treatment and study plan

Shear wave elastography to distinguish AKI from normal kidney

Diagnostic Test

Record the patient's kidney size, cortical thickness, possible lesion by ordinary renal sonography as well as cortical elasticity by shear wave elastography

Shear wave elastography to distinguish AKI from CKD

Diagnostic Test

Record the patient's kidney size, cortical thickness, possible lesion by ordinary renal sonography as well as cortical elasticity by shear wave elastography

Shear wave elastography to distinguish CKD from normal kidney

Diagnostic Test

Record the patient's kidney size, cortical thickness, possible lesion by ordinary renal sonography as well as cortical elasticity by shear wave elastography

Primary outcomes

  1. To determine the correlation of kPa ratio and renal function in chronic renal disease

    Time frame: change in renal function after 2 weeks

    The analysis will be conducted to determine the correlation between kPa ratio measured by elastography and renal function in patients with chronic renal disease

Study contacts

Contact information is provided by the study sponsor or research team.

Jia Yu Chen, Resident

CONTACT

[email protected]

+886 972652447

Wan C. Lien, A.P

CONTACT

[email protected]

+886 972651315

Sponsors and collaborators

Lead sponsor

National Taiwan University Hospital

Other

Registry information

Acronym: CKD-SWE

Important dates

Study start
2020
Primary completion
2026
Study completion
2026
First posted
May 27, 2020
Registry last updated
Nov 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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