Shear-wave Elastography Compared to Respiratory Function Testing

The purpose of this study is to evaluate the relationship between transdiaphragmatic pressure (Pdi) and diaphragm shear-wave elastography (SWE) during state-of-the-art respiratory muscle testing including volitional efforts (e.g., maximal inspiratory pressure, maximal expiratory pressure, Valsalva maneuver), as well as maximal phrenic nerve stimulation.

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Key information

Conditions

Respiratory Function Loss Respiratory Complication

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

Location status: Recruiting

Location contact

Carlos B Mantilla

CONTACT

[email protected]

507-255-1612

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult male and female healthy volunteers.

Exclusion criteria

Volunteers who are pregnant.
Volunteers with known pulmonary pathology (COPD, asthma requiring routine treatment).

Treatment and study plan

shear-wave elastography

Diagnostic Test

Ultrasound based imaging of diaphragm muscle activity

Primary outcomes

Shear wave speed

Time frame: 3 hours

Elastography of the diaphragm muscle across various behaviors and conditions

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Official study title

Comparison of Shear-wave Elastography to State-of-the-art Respiratory Function Testing to Measure the Range of Forces Generated by the Diaphragm Muscle

Important dates

Study start: 2021
Primary completion: 2026
Study completion: 2026
First posted: Jul 13, 2021
Registry last updated: Mar 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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