NCT Number: NCT03063216
The purpose of this study is to evaluate the long-term visual outcome of the cataract surgery using a large-scale and comprehensive database of pediatric cataract participants, including congenital and traumatic cataract. The investigators will further investigate into the various genetic and environmental factors that may contribute to the pathogenesis of pediatric cataract.
Interested in participating?
Request Info2 month–20 year
All sexes
Observational
Shanghai, Shanghai Municipality, 200031, China
Location status: Recruiting
Keke Zhang, M.D.
CONTACT
Ruiqi Chang, M.D.
CONTACT
Wenwen He, M.D.
CONTACT
Xiangjia Zhu, M.D.
CONTACT
Yi Lu, MD
CONTACT
Yinglei Zhang, M.D.
CONTACT
Yu Du, M.D.
CONTACT
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
1）Pediatric cataract patients with intraocular lens implantation and those without intraocular lens implantation；2）Traumatic cataract patients with intraocular lens implantation and those without intraocular lens implantation
Time frame: Follow-up until ten years after surgery.
Visual outcomes are evaluated including visual acuity with or without correction, refractive changes, intraocular pressure, fundus function, fixation type, vision development, growth of axial length, contrast sensitivity and other visual outcome measurements.
Time frame: Analyzed within six months after surgery.
Sequencing of genes (including exons, promoters, 5' UTR and 3' UTR sequences) on a large scale to intensively investigate into the sites and functions of single nucleotide polymorphism (SNP) correlated with clinical features of congenital cataract patients, compared to traumatic cataract patients.Samples of blood, aqueous humor, anterior capsular membranes and lens tissues were applied for the genetic analysis.
Time frame: Evaluated before receiving the cataract surgery.
Cataract type and severity of ametropic cataract patients are evaluated and images are captured before receiving the cataract surgery.
Contact information is provided by the study sponsor or research team.
Evidence Based Cataract Study Group
Other
Visual Outcome Evaluation and Genetic Analysis: Shanghai Pediatric Cataract Study
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