Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing

Growth hormone deficiency affects disproportionately more males than females. Although ascertainment bias plays a role in this sexual dimorphism, no plausible mechanism to fully explain this difference has been proposed.

This investigator initiated study will provide currently unavailable data on sexual/age differences in response to GH stimulation testing. Data obtained from the study may provide a basis for developing appropriate normal ranges for adult GH testing, may provide a plausible mechanism for the enhanced hormone responsiveness observed in females, and may provide data on when the sexual differences to GH stimulation may develop.

The objectives of this study are to:

• Confirm the sexual dimorphism in growth hormone responses for adult growth hormone testing in healthy male and female subjects
• Correlate peak Growth Hormone Releasing Hormone (GHRH)/arginine induced growth hormone responses with G protein levels in healthy subjects and in patients with a history of childhood GH deficiency
• Determine whether sexual dimorphism is acquired during puberty

Inclusion criteria

Healthy subjects

• Males and females, Tanner stage V aged 15-40 years of age with no known endocrine problems
• Males and females, Tanner stage I, aged 5-8 years with no known endocrine problems

GH subjects - Males and females, Tanner stage V, aged 15-21 years with a history of childhood growth hormone deficiency

Exclusion criteria

Healthy subjects

• History of GH deficiency or treatment or other known endocrine disorder
• Current height or adult height <5th %
• Female subjects using hormonal methods of birth control
• Female subjects with irregular menstrual cycles

GH subjects

• Subjects with GH deficiency who have not discontinued GH treatment for at least 2 months