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NCT Number: NCT04880590

Sex or no Sex: That is the Question.

This study aims to evaluate the impact of sexual intercourse and orgasm in the 72 hrs following embryo transfer of blastocysts on the clinical pregnancy rate.

An impact on sexual activity and a decrease in the frequency of intercourse has been observed in infertile couples. In couples who undergo assisted reproductive technology (ART), sexual relations have an additional component that can condition them, such as the fear of influencing the outcome of the cycle.

The usual practice in ART cycles has evolved towards a preference for blastocyst-stage embryo transfer, both in fresh in vitro fertilization (IVF) cycles and in frozen embryo transfer (FET) cycles.

The investigators consider it important to elucidate whether coital intercourse after embryo transfer (ET) has an impact on the clinical pregnancy rate after the transfer of blastocyst-stage embryos.

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Key information

Conditions

Infertility, Female Behavior Coitus Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Infertility Sexual Behavior Sexual Intercourse Urogenital Diseases

Sex eligibility

Female

Study type

Observational

Primary location

Hospital Universitario Quiron Dexeus

Barcelona, 08028, Spain

Location status: Recruiting

Location contact

Ignacio Rodríguez, MSc

CONTACT

[email protected]

0034932274700

About this study

It is proposed to carry out an observational, prospective study, in which women with a heterosexual sexual relationship are included, who carry out an embryo transfer, in a FET cycle in the Dexeus Woman Reproduction Medicine Service and who agree to participate in the same.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Women with a heterosexual sexual relationship
  • That they carry out an embryo transfer, in a FET cycle

Exclusion criteria

  • Exclusion criteria are not foreseen

Treatment and study plan

Sex intercourse

Other

A heterosexual sexual relationship

Primary outcomes

  1. Clinical pregnancy rate

    Time frame: 6-7 weeks after transfer

    Clinical pregnancy rate measured by ultrasound with the presence of a positive fetal heartbeat

Secondary outcomes

  1. Miscarriage rate

    Time frame: Until 13 weeks after embryo transfer procedure

    The loss of a pregnancy during the first 13 weeks of pregnancy

  2. Live birth rate

    Time frame: Until 42 weeks after embryo transfer

    Number of live birth after embryo transfer

Study contacts

Contact information is provided by the study sponsor or research team.

Ignacio Rodríguez, MSc

CONTACT

[email protected]

0034932274700

Isabeth Gonzalez de Campagnolo, MD

CONTACT

[email protected]

0034932274700

Sponsors and collaborators

Lead sponsor

Fundación Santiago Dexeus Font

Other

Registry information

Official study title

Sex or no Sex: That is the Question. Impact of Coital Sexual Intercourse on the Clinical Pregnancy Rate After Embryo Transfer.

Important dates

Study start
2021
Primary completion
2025
Study completion
2026
First posted
May 11, 2021
Registry last updated
Mar 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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