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NCT Number: NCT07398976

Sex Differences in E-Cigarette Perception

This study examines differences between males and females in the appeal and addiction potential of menthol flavored e-cigarettes with and without nicotine.

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Key information

Conditions

Nicotine Dependence Behavior Chemically-Induced Disorders E-cigarette Use Mental Disorders Smoking Substance-Related Disorders Tobacco Use Disorder Vaping

Age range

21 year–44 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

The goal of this protocol is to investigate how sex differences in response to menthol and nicotine influence product preference and choice. In this proposal, participants will be exposed to menthol non-nicotine and nicotine containing e-cigarettes and product preference and choice will be examined in a paradigm where a menthol nicotine-containing e-cigarette is progressively more difficult to earn, and a menthol non-nicotine e-cigarette is available at a low, fixed cost. Additionally, it will be investigated how menthol e-cigarettes with and without nicotine impact reward, appeal, and sensory effects in an initial sampling session (secondary and exploratory outcomes).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Able to read/write in English
  • Current cigarette smoking
  • Prior e-cigarette exposure
  • Biochemically verified cigarette use
  • Not trying to quit tobacco use

Exclusion criteria

  • Significant medical concerns that would increase study risk
  • Use of psychoactive drugs unless prescribed and stable
  • Allergy to menthol or other e-liquid ingredients
  • Dislike of menthol
  • Pregnant, trying to get pregnant, breastfeeding

Treatment and study plan

Nicotine Level 1 (0mg/ml)

Other

Menthol with be paired with 0mg/ml nicotine in an e-cigarette

Nicotine Level 2 (36mg/ml)

Other

Menthol with be paired with 36mg/ml nicotine in an e-cigarette

Nicotine Level 3 (59mg/ml)

Other

Menthol with be paired with 59mg/ml nicotine in an e-cigarette

Primary outcomes

  1. Proportion of Choices

    Time frame: For the 3 hour period of the Lab 2 preference task

    Differences in proportion of choices for the two menthol e-cigarette for males and females in the Lab 2 preference task

  2. Breakpoint

    Time frame: During the 3 hour period of the Lab 2 preference task

    Difference in highest point of the progressive ratio schedule obtained between males and females

Secondary outcomes

  1. Reward

    Time frame: Immediately (~2 minutes) after e-cigarette exposures in Lab 1

    Difference in scores (range: 0-100) of the Liking/Wanting Subscale of the Drug Effects Questionnaire

Study contacts

Contact information is provided by the study sponsor or research team.

Danielle R Davis, PhD

CONTACT

[email protected]

2039747607

Sponsors and collaborators

Lead sponsor

Yale University

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)

Registry information

Official study title

Sex Differences in E-Cigarette Perception: Study 2

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Feb 10, 2026
Registry last updated
Jul 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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