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OpenTrials
Completed

NCT Number: NCT00000259

Sevoflurane vs Nitrous Oxide Inhalation at Subanesthetic Concentrations - 11

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To examine sevoflurane versus isoflurane inhalation at subanesthetic concentrations on mood, pain, and psychomotor performance.

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Key information

Conditions

Opioid-related Disorders Chemically-Induced Disorders Mental Disorders Narcotic-Related Disorders Substance-Related Disorders

Age range

21 year–39 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Chicago, Anesthesia & Critical Care

Chicago, Illinois, 60637, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Please contact site for information.

Treatment and study plan

15 % Nitrous oxide

Drug

0.3 % Sevoflurane

Drug

30% Nitrous oxide

Drug

0.6% Sevoflurane

Drug

Placebo

Other

Primary outcomes

  1. Pain intensity

    Time frame: 30 min of inhalation

    Subjects underwent a 3 min cold immersion test at 30 min of inhalation and then provided response to pain intensity questionnaire

  2. Psychomotor performance

    Time frame: Baseline, 5 min of inhalation; 5, 30, 60 minutes recovery

    Subjects underwent psychomotor testing at baseline, during inhalation, and during recovery post inhalation

  3. Cognitive performance

    Time frame: Baseline, every 5 min during inhalation, 5, 30, & 60 min during recovery

    Subject underwent memory, sedation, visual analog, and drug effects testing

Sponsors and collaborators

Lead sponsor

University of Chicago

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)

Registry information

Official study title

Sevoflurane vs Nitrous Oxide Inhalation at Subanesthetic Concentrations

Important dates

Study start
1996
Primary completion
1997
Study completion
1997
First posted
Sep 21, 1999
Registry last updated
May 28, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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