Skip to main content
OpenTrials
Completed

NCT Number: NCT06666959

Sevoflurane Versus Propofol in Endovascular Coiling of Cerebral Aneurysm

The goal of this observational study is to learn about the anti-inflammatory effects of anesthetics on patients undergoing endovascular coiling of cerebral aneurysm. The main question it aims to answer is:

Does sevoflurane or propofol affect the inflammatory response in subarachnoid hemorrhage?

Participants already undergoing endovascular coiling of cerebral aneurysm will have their serum levels of inflammatory factors measured.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Propofol Sevoflurane

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Neurosurgery

Wuhan, Hubei, 430030, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Consecutive patients aged 18 years and older presenting to the Tongji hospital for endovascular coiling of cerebral aneurysm were eligible for enrollment.

Exclusion criteria

  • have an endocrine system disease
  • pregnancy
  • have other brain disorders
  • take drugs that alter endocrine hormones
  • receive perioperative blood derivatives

Treatment and study plan

Anesthesia Agent

Drug

intravenous anesthetic and inhalation anesthetic

Other names: sevoflurane, propofol

Primary outcomes

  1. Concentration of interleukin-10

    Time frame: From enrollment to 3 months postoperation

    Test the concentration of interleukin-10 of the participants

Secondary outcomes

  1. Concentration of interleukin-1

    Time frame: From enrollment to 3 months postoperation

    Test the Concentration of interleukin-1 in participants

  2. Concentration of interleukin-2

    Time frame: From enrollment to 3 months postoperation

    Test the concentration of interleukin-2 in participants

  3. Concentration of interleukin-6

    Time frame: From enrollment to 3 months postoperation

    Test the concentration of interleukin-6 in participants

  4. Concentration of interleukin-8

    Time frame: From enrollment to 3 months postoperation

    Test the concentration of interleukin-8 in participants

  5. Concentration of tumor necrosis factor

    Time frame: From enrollment to 3 months postoperation

    Test the concentration of tumor necrosis factor in participants

  6. Concentration of S100B

    Time frame: From enrollment to 3 months postoperation

    Test the concentration of S100B in participants

  7. length of stay

    Time frame: through study completion, an average of 6 months

    The time from admission to discharge

  8. costs

    Time frame: through study completion, an average of 6 months

    Hospitalization expenses

  9. Glasgow Coma Score

    Time frame: From enrollment to 3 months postoperation

    The scores are ranging from 3 to 15. And higher scores mean a betterr outcome .

Sponsors and collaborators

Lead sponsor

Tongji Hospital

Other

Registry information

Official study title

Comparison of the Neuroprotective Effect of Sevoflurane Versus Propofol in Patients Undergoing Endovascular Coiling of Cerebral Aneurysm

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Oct 31, 2024
Registry last updated
Oct 31, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.