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OpenTrials
Completed

NCT Number: NCT04788537

Services to Enhance Social Functioning in Adults With Autism Spectrum Disorders

The purpose of this study is to test a novel, three-part cognitive behavioral treatment strategy to improve social functioning in adults with autism spectrum disorder.

The treatment, named TUNE In (Training to Understand and Navigate Emotions and Interactions), includes components to address the many behavioral domains involved in social functioning, including social motivation, social anxiety, social cognition, social skills, and generalization of the skills to community settings.

The Investigators will test the efficacy of TUNE In to improve social functioning in adults with autism spectrum disorder (ASD), using a randomized controlled trial using the SRS-2 as the primary outcome measure.

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Key information

Conditions

Autism Asperger Syndrome Autism Spectrum Disorder Autistic Disorder Child Development Disorders, Pervasive Mental Disorders Neurodevelopmental Disorders Pervasive Developmental Disorder

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Perelman School of Medicine

Philadelphia, Pennsylvania, 19104, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diagnosis of autism spectrum disorder

Exclusion criteria

  • intellectual disability
  • severe mood or psychotic symptoms experienced in the past 4 weeks
  • severe self-injurious or aggressive behavior
  • severe extrapyramidal motor or sedating side effects of medications
  • concomitant participation in another social skills treatment program.

Treatment and study plan

Training to Understand and Navigate Emotions and Interactions (TUNE In)

Behavioral

A three-part cognitive behavioral treatment strategy to improve social functioning in adults with autism spectrum disorder. TUNE In includes components to address the many behavioral domains involved in social functioning, including social motivation, social anxiety, social cognition, social skills, and generalization of the skills to community settings.

Primary outcomes

  1. Reduction in Social Responsiveness Scale, Second Edition (SRS-2) - Adult (Relative/Other Report)

    Time frame: Baseline and Post-Treatment (~1 year after baseline)

    Scale ranges from 30 to 90 with higher T-scores indicating greater severity of autism symptomatology.

Sponsors and collaborators

Lead sponsor

University of Pennsylvania

Other

Registry information

Important dates

Study start
2021
Primary completion
2023
Study completion
2023
First posted
Mar 9, 2021
Registry last updated
Mar 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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