Serum Uromodulin and DN Systematic Review and Meta Analysis

Several studies have investigated the association between the changes of serum uromodulin and diabetic nephropathy (DN). However, the results are still controversial. Hence, this meta-analysis aimed to evaluate the association of uromodulin with DN.

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Key information

Conditions

Diabetic Nephropathies Diabetes Complications Diabetes Mellitus Endocrine System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Urogenital Diseases Urologic Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Tanta Yniversity

Tanta, Yes, 31511, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Studies were included if they met the following criteria:

serum level of uromodulin was determined;
the samples were enrolled from diabetic patients;
mean ± SD was reported for uromodulin between patients with and without DN;
the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN was determined

Exclusion criteria

Studies were excluded according to the following criteria:

duplicate studies;
review articles;
non original research articles;
studies with insufficient data to extract;
non-human research;
studies that determined urine level of uromodulin.

Treatment and study plan

The association of serum uromodulin with DN

Diagnostic Test

Meta analysis of association of serum uromodulin with DKD

The DN patients were divided according to the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN

Diagnostic Test

DN patients were divided according to the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN

Primary outcomes

Association of serum uromodulin with DKD: asystematic review and meta analysis

Time frame: may, 2024

Evaluate the meta analysis of association of serum uromodulin in the 3 diabetic group comparing with each other and compare them to the control group and correlate these results with other kidney biomarker

Sponsors and collaborators

Lead sponsor

Tanta University

Other

Collaborators

Ain Shams University

Registry information

Official study title

Association of Serum Uromodulin and DKD a Systematic Review and Meta Analysis

Important dates

Study start: 2024
Primary completion: 2024
Study completion: 2024
First posted: Sep 19, 2024
Registry last updated: Sep 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed