Serum Resistin Level Following Non-surgical Periodontal Therapy in Diabetic Patients With Chronic Periodontitis

Background: Resisitin is a recognized marker for chronic inflammatory conditions that could be directly linked with type 2 diabetes mellitus. The aim of this study was to assess serum resistin level in type 2 diabetic patients with chronic periodontitis.

Methods: Forty individuals were recruited in this study and were divided into three groups, diabetic group consisted of 15 diabetic patients (type 2 diabetes mellitus) with moderate to severe chronic periodontitis, non-diabetic group consisted of 15 non-diabetic patients with moderate to severe chronic periodontitis and healthy group consisted of 10 non-diabetic individuals with healthy periodontium. Non-surgical periodontal therapy with supra and subgingival debridement was performed for the diabetic and non-diabetic groups. Pocket depth, clinical attachment level, plaque index, gingival index, serum Resistin and high sensitivity C-Reactive Protein assay were recorded for both groups before and after treatment, while HbA1c was recorded for the diabetic group.

Inclusion criteria

• diagnosed with moderate to severe chronic periodontitis.
• Presence of a minimum of 15 natural teeth
• Presence of at least four teeth with one or more sites with probing pocket depth (PPD) ≥5mm and clinical attachment level (CAL) ≥4mm
• agreement to participate in the study and sign a written informed consent

Exclusion criteria

• Patients who received any periodontal treatment or professional scaling and root planing of the teeth for at least 6 months prior to the study initiation
• A history of antibiotics therapy and anti-inflammatory drugs within the previous 6 months
• Pregnancy or use of contraceptives or any medication related to diabetes
• former or current smokers ˂ 5 years.