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Completed

NCT Number: NCT03041480

Serum Lipid Levels and Lp-PLA2 in Chronic Periodontitis

To assess the association between periodontal parameters, serum lipid profile and Lp-PLA2 level in systemically healthy Chronic Periodontitis subjects and healthy controls.

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Key information

Conditions

Chronic Periodontitis (Disorder) Chronic Disease Chronic Periodontitis Disease Attributes Mouth Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases Periodontitis Stomatognathic Diseases

Age range

35 year–64 year

Sex eligibility

All sexes

Study type

Observational

About this study

Seventy five participants were divided into 3 groups. The groups consisted of GROUP I- generalized severe chronic periodontitis, GROUP II- generalized moderate chronic periodontitis and GROUP III- systemically and periodontally healthy volunteers who served as control. The selected patients were then evaluated for periodontal parameters, lipid profile and Lp-PLA2.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Group I:

  • Subjects with age ≥ 35 years.
  • Presence of at least 24 teeth, with Clinical attachment loss (CAL) ≥ 5mm in more than 30% of sites.

Group II:

  • Subjects with age ≥ 35 years.
  • Presence of at least 24 teeth, with Clinical attachment loss (CAL) between 3-4 mm in more than 30% of sites.

Group III:

  • Subjects with age ≥ 35 years.
  • Healthy and intact periodontium

Exclusion criteria

  • Presence of any systemic disease or conditions that could affect periodontal tissues.
  • History of periodontal treatment in past 6 months.
  • Smoking and alcoholism
  • Anomalies of blood and immune system
  • Systemic medication or antibiotic treatment for the previous 6 months.
  • Pregnant females.

Treatment and study plan

serum lipid levels and Lp-PLA2

Diagnostic Test

Estimation of Total Cholesterol, triglyceride, High density lipoprotein, Low density lipoprotein, very low density lipoprotein and Lipoprotein associated lipophosphase A2 in chronic periodontitis

Other names: Biological marker

Primary outcomes

  1. Estimation of serum Lp-PLA2

    Time frame: 9 months

    Serum Lp-PLA2 was estimated in all the groups using ELISA

Secondary outcomes

  1. Estimation of serum lipid profile

    Time frame: 9 months

    Serum Total cholesterol, triglyceride, High density lipoprotein, Low density lipoprotein and very low density lipoprotein

Sponsors and collaborators

Lead sponsor

Meenakshi Ammal Dental College and Hospital

Other

Registry information

Official study title

The Association Between Periodontal Status, Serum Lipid Levels and Lipoprotein Associated Lipophosphase A2(Lp-PLA2) in Chronic Periodontitis Subjects and Healthy Controls: A Case Control Study

Important dates

Study start
2015
Primary completion
2015
Study completion
2015
First posted
Feb 2, 2017
Registry last updated
Feb 2, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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