Serum Free Fatty Acid Metabolite Biomarkers of Lung Cancer

This study aims to evaluate the performance of serum free fatty acids as biomarkers for the identification of lung cancer.

Completed

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Key information

Conditions

Lung Cancer Biomarkers Fatty Acids Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

40 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Cleveland Clinic

Cleveland, Ohio, 44195, United States

About this study

We will compare the concentration of free fatty acids and their metabolites between patients with lung cancer and control pulmonary patients without known cancer. The diagnostic accuracy will be assessed for potential predictors.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age from 40 to 80
Lung adenocarcinoma with pathological diagnosis
Lung squamous cell carcinoma with pathological diagnosis
Control patients should have at least one of the following criteria: (1) current or ex-smoker with at least a 10 pack-year history, (2) a first-degree relative with a history of lung cancer, or (3) a clinical diagnosis of COPD.

Exclusion criteria

Lung cancer patient without serum sample before the initiation of treatment

Treatment and study plan

serum sample

Other

Serum samples from lung cancer patients were collected at the time of their diagnosis, prior to the initiation of treatment. Serum samples of control subjects were collected from a biobank

Primary outcomes

Compare Concentration of Fatty Acids and Their Metabolites

Time frame: At the time of diagnosis, prior to the initiation of lung cancer treatment

Biochemical analysis of serum sample was conducted by an investigator who was strictly blinded to cancer status and patient characteristics.

Sponsors and collaborators

Lead sponsor

The Cleveland Clinic

Other

Registry information

Important dates

Study start: 2012
Primary completion: 2014
Study completion: 2014
First posted: Sep 26, 2012
Registry last updated: Jun 20, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed