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NCT Number: NCT06869109

Serum CXCL10 and CRP Levels in Patients With Acne Vulgaris in Correlation With Disease Severity

the correlations between CXCL10 levels, CRP, and acne severity scores (e.g., Global Acne Grading System) suggest that CXCL10 could serve as a biomarker of inflammation and acne severity. Understanding the relationship between CXCL10, CRP, and acne severity may offer insights into novel therapeutic strategies targeting inflammatory pathways in acne.

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Key information

Conditions

Acne Vulgaris Acneiform Eruptions Sebaceous Gland Diseases Skin Diseases Skin and Connective Tissue Diseases

Age range

12 year–40 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Assiut University

Asyut, Asyut Governorate, 71515, Egypt

About this study

Cross-sectional Observational Study. using 4 groups a 3 of different acne severity and controle one . the serum cxcl10 and crp will measured in each patient to correlate with disease severity

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 12-40 years diagnosed with acne vulgaris.
  • Both genders included.
  • Patients with mild, moderate, or severe acne severity as determined by a validated scoring system (e.g., Global Acne Grading System).
  • Patients not on systemic acne treatment (e.g., isotretinoin or antibiotics) or anti-inflammatory drugs.

Exclusion criteria

  • Patients with autoimmune diseases, systemic illnesses, acute infection or any other chronic inflammatory conditions that may affect CRP or CXCL10 levels.
  • Pregnant or lactating individuals.

Treatment and study plan

serum cxcl10

Diagnostic Test

serum blood sample to measure the cxcl10

serum crp

Diagnostic Test

blood sample to measure crp

Primary outcomes

  1. Correlation of CXCL10 and CRP levels with acne severity (GAG score).

    Time frame: within one year after the result

    compare the result of serum cxcl10 and crp with disease severity

Secondary outcomes

  1. Identify thresholds of CXCL10 and CRP for predicting moderate/severe acne

    Time frame: within one year after the result

    the least result to identify the group

  2. Explore potential differences based on sex or age groups

    Time frame: within one year of the result

    the effect of age and sex on the result

Study contacts

Contact information is provided by the study sponsor or research team.

Dina Essam, physician

CONTACT

[email protected]

+201027664829

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Acronym: CXCL10

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Mar 11, 2025
Registry last updated
Mar 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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