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NCT Number: NCT07020624

Serratus Posterior Superior Intekcostal Plane Block vs Serratus Anterior Plane Block for Postoperative Analgesia in VATS: A Randomized Trial"

Thoracotomy is known as one of the most painful surgical procedures, with up to 65% of patients developing chronic post-thoracotomy pain syndrome (PTPS), and approximately 10% experiencing pain that significantly impacts quality of life. Video-assisted thoracoscopic surgery (VATS) has become increasingly common over the past decade and offers reduced postoperative pain, morbidity, and length of hospital stay compared to open thoracotomy. However, VATS can still cause moderate to severe postoperative pain and a high risk of chronic pain. Optimizing analgesia after VATS remains critical. With advances in ultrasound technology, several regional anesthesia techniques such as serratus anterior plane block (SAPB), erector spinae plane block (ESPB), and thoracic epidural analgesia (TEA) have shown comparable efficacy. In 2023, Tulgar et al. described the serratus posterior superior intercostal plane block (SPSIPB), which demonstrated dermatomal coverage from C3 to T10. This randomized controlled trial aims to compare the analgesic efficacy of SPSIPB and SAPB in patients undergoing VATS procedures.

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Key information

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Samsun University,

Samsun, Ilkadım, 55100, Turkey (Türkiye)

Location contact

gamze ertaş, specialist

CONTACT

[email protected]

5056587914

gamze ertaş, specialist

SUB_INVESTIGATOR

hamiyet şenol çakmak, specialist

PRINCIPAL_INVESTIGATOR

necmiye gül temel, specialist

SUB_INVESTIGATOR

About this study

The patients will be divided into two groups and all will receive general anesthesia. Before extubation, one group will receive a Serratus Anterior Plane Block, and the other group will receive a Serratus Posterior Superior Intercostal Plane Block. The randomization of the study will be performed by a physician who will not be involved in the patient follow-up, using a computer-generated randomization code (generated by the computer). The interfascial plane block (Serratus Anterior Plane Block or Serratus Posterior Superior Intercostal Plane Block) will be given to the anesthesiologist in a sealed envelope by an independent assistant personnel outside the study. The patient will not be aware of which block is being applied. The anesthesiologist performing the block will not participate in the patients' pain monitoring. Postoperative pain assessment and data collection will be performed by another anesthesiologist who is unaware of the study.

For standardization purposes, the block procedure will be performed by an experienced anesthesiologist who has performed at least 20 successful and uncomplicated procedures before.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI < 35 kg/m² Patients with ASA scores I, II, III

Exclusion criteria

  • Patients who do not want to be included in the study Psychiatric and neurological disease with blurred consciousness Patients with ASA > 3 BMI > 35 kg/m² Abnormality in coagulation parameters History of allergy to local anesthetic drugs Infection at the injection site Patients whose surgical procedure time exceeds 150 minutes

Treatment and study plan

SAPB

Other

Ultrasound guided serratus anterior plane block will be performed.

SPSIPB

Other

Ultrasound guided serratus posterior superior intercostal plane block will be performed.

Primary outcomes

  1. Morphine consumption in the first 24 hours postoperatively

    Time frame: up to 24 hours

    Morfin consumption in the first 24 hours after surgery

Secondary outcomes

  1. Pain density

    Time frame: up to 24 hours.

    NRS scores (Numeric rating scale; 0: no pain, 10: severe pain) in the first 24 hours after surgery

  2. Quality of recovery

    Time frame: 24 hours after surgery

    QR15 scores

  3. Nausea and vomiting

    Time frame: up to 24 hours

    Nausea and vomiting scores in the first 24 hours (verbal rating scale; 0= none, 1= nausea, 2= gagging, 3= vomiting)

  4. shoulder pain

    Time frame: up to 24 hours

    postoperative shoulder pain;shoulder pain will be evaluated as present/absent

Study contacts

Contact information is provided by the study sponsor or research team.

gamze ertaş, specialist

CONTACT

[email protected]

5056587914

hamiyet şenol çakmak, specialist

CONTACT

[email protected]

3623111500 ext. 1128

Sponsors and collaborators

Lead sponsor

Samsun University

Other

Registry information

Official study title

Comparison of the Analgesic Effects of Serratus Posterior Superior Intercostal Plane Block (SPSIPB) and Serratus Anterior Plane Block (SAPB) on Postoperative Analgesia in Video-Assisted Thoracoscopic Surgery (VATS)

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jun 13, 2025
Registry last updated
Jun 13, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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