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Completed

NCT Number: NCT04579302

Serratus Anterior Block and Erector Spinae Block in Postoperative Analgesia

90 patients scheduled for thoracic cancer surgeries, allocated in 3 groups for serratus anterior block and erector spinae block and control group. during anaesthesia:total intraoperative fentanyl required will be recorded. After surgery, all patients will be connected to PCA device containing morphine solution, the amount of morphine consumed during the first 24 hours will be recorded.

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Key information

Conditions

Postoperative Analgesia

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

National Cancer Institute

Cairo, Egypt

About this study

90 patients scheduled for thoracic cancer surgeries, allocated in 3 groups for serratus anterior block (SAB) and erector spinae block (ESB) and control group. During anaesthesia: total intraoperative fentanyl required will be recorded. After surgery, all patients will be connected to PCA device containing morphine solution, the amount of morphine consumed during the first 24 hours will be recorded. Other secondary outcomes are: numerical rating scales and postoperative pulmonary functions.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with class II physical status (American Society of Anaesthesiologists) ,
  • Age between 18-70 years,
  • Scheduled for thoracic cancer surgery

Exclusion criteria

  • Patient refusal.
  • Local infection at the site of the block.
  • Cardiac dysfunction (ejection fraction <45%).
  • Significant respiratory disorders.
  • Preexisting neurological or psychiatric disease.
  • Allergy to one of the study drugs.
  • Pregnancy.
  • Coagulopathy

Treatment and study plan

Serratus anterior block (SAB)

Procedure

Patients will receive a sonar guided serratus anterior plane block with 20 ml of bupivacaine 0.5%

Other names: SAB group

erector spinae block

Procedure

Patients will receive a sonar-guided erector spinae plane block with 20 ml of bupivacaine 0.5%

Other names: ESB group

Saline (as a placebo)

Drug

Patients will receive a sham block with 20 ml saline (as a placebo)

Bupivacaine

Drug

bupivacaine

Primary outcomes

  1. total morphine consumption in first postoperative 24 hours

    Time frame: first 24 postoperative hours

    the amount of morphine required to relieve pain will be recorded

Secondary outcomes

  1. intraoperative fentanyl requirement

    Time frame: during anaesthesia

    the amount of fentanyl required during anaesthesia will be recorded

  2. numerical rating scale

    Time frame: the first 24 postoperative hours

    numerical rating scale (from 0 to 10, where 0 represents no pain and 10 represents the worst imaginable pain) will be recorded in different time intervals during the first 24 hours after surgery

  3. pulmonary functions

    Time frame: 24 hours after surgery

    FVC and FEV1 will be recorded at 24 hours after surgery

Sponsors and collaborators

Lead sponsor

National Cancer Institute, Egypt

Other

Registry information

Official study title

Evaluation of the Effect of Serratus Anterior Block and Erector Spinae Block on Postoperative Analgesia in Thoracic Surgeries

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Oct 8, 2020
Registry last updated
Mar 9, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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