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Completed

NCT Number: NCT00297505

Serotonin, Impulsivity, and Cocaine Dependence Treatment

The purpose of this study is to compare the effects of citalopram versus placebo given in the context of contingency management for cocaine dependence.

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Key information

Conditions

Cocaine Dependence Behavior Chemically-Induced Disorders Cocaine-Related Disorders Impulsive Behavior Mental Disorders Substance-Related Disorders

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

University of Texas - Houston Health Science Center

Houston, Texas, 77030, United States

About this study

Cocaine dependence continues to be a significant public health problem, for which there is no FDA approved pharmacotherapy. This study is a 12-week, double blind, placebo controlled trial of citalopram for cocaine dependence. The primary outcome measure is benzoylecgonine positive urines. Secondary measures of side effects and craving are also examined.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • male and female subjects age 18 to 50 who currently meet DSM-IV criteria for cocaine dependence.
  • female subjects: a negative pregnancy test

Exclusion criteria

  • current or past DSM-IV Axis I disorder other than substance abuse/dependence
  • any serious non-psychiatric medical illness requiring ongoing medical treatment
  • substance dependence other than cocaine within the last 3 months
  • negative urine drug screen for cocaine at time of testing
  • for female subjects: a positive pregnancy test

Treatment and study plan

Citalopram

Drug

Primary outcomes

  1. The presence of cocaine metabolites in urine weekly.

Secondary outcomes

  1. Retention rate and cocaine cravings weekly.

Sponsors and collaborators

Lead sponsor

National Institute on Drug Abuse (NIDA)

Nih

Registry information

Important dates

Study start
2001
Study completion
2004
First posted
Feb 28, 2006
Registry last updated
Jan 12, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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