Serological Response to mRNA and Inactivated COVID-19 Vaccine in Health Care Workers in Hong Kong

Since the first local case of COVID-19 confirmed on 4 Feb 2020, Hong Kong has already experienced 4 waves of COVID-19 surge, with more than 9000 cases reported. A number of vaccines have been shown to be efficacious against symptomatic and severe infection by inducing neutralizing antibody (NAB) against spike protein of the SARS-CoV-2 virus. However, the duration of protection and longevity of antibody response is unknown.

Health care workers (HCWs) who are planning to receive COVID-19 vaccine will be recruited. The level of antibody against spike protein by different quantitative assays will also be serially measured .

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Key information

Conditions

COVID-19 Vaccine

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hong Kong Sanatorium & Hospital

Hong Kong

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Any staff, visiting doctor, nursing student of HKSH who are aged 18 or above
No contraindication for COVID-19 vaccination and plan to receive the intended dosages at the appropriate interval.
A baseline serology taken within 1 week before vaccination shows no evidence of recent infection.
No history of documented COVID-19 infection

Exclusion criteria

Treatment and study plan

CoronaVac vaccine

Biological

CoronaVac Vaccine

BNT162b2 Vaccine

Biological

Covid-19 BNT162b2 Vaccine

Primary outcomes

Change of IgG Level in the serum of healthcare workers who received COVID-19 vaccine

Time frame: 1 month, 3 months and 6 months post vaccination

Change of IgG Level in the serum of healthcare workers who received COVID-19 vaccine at different points during the first six months of vaccination

Sponsors and collaborators

Lead sponsor

Hong Kong Sanatorium & Hospital

Industry

Registry information

Important dates

Study start: 2021
Primary completion: 2021
Study completion: 2021
First posted: May 24, 2021
Registry last updated: Feb 28, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed