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Completed

NCT Number: NCT07741578

Sequential Order of RSI on Tracheal Intubation

This clinical trial aims to understand the effect of the order of administration of Neuromuscular Blocking Agents (NMBAs) and sedatives on the success rate of intubation during Rapid Sequence Intubation (RSI) in the emergency department. The main questions to be answered include:

1. The impact of sequential drug administration order during rapid sequence induction (RSI) on first-pass intubation success rates. 2. Time to successful intubation 3. Hypoxia incidence (SpO₂ <90%) 4. Risk of post-traumatic stress disorder (PTSD) 5. Procedure-related complications

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Key information

Conditions

Tracheal Intubation Rapid Sequence Induction and Intubation

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Zhongnan Hospital of Wuhan University

Wuhan, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • in ED/EICU required emergency intubation
  • RSI required

Exclusion criteria

  • Pregnancy
  • do not intubation orders
  • Declined participation
  • Other trials
  • Non-emergent cases
  • Active CPR

Treatment and study plan

Drug Sequence

Procedure

Control: Sedative ( Propofol ) →within 30s→ NMBA ( Rocuronium ) → Intubation → 5min → Measure vital signs → After treatment → Remove tracheal intubation→ Recall of intubation Intervention: NMBA ( Rocuronium ) →within 30s→ Sedative(Propofol) → Intubation → 5min → Measure vital signs → After treatment → Remove tracheal intubation→ Recall of intubation

Primary outcomes

  1. First-pass success rate

    Time frame: Perioperative

    Successful intubation on the first attempt, confirmed by any one of:

    Direct visualization of the ETT passing through vocal cords Bilateral breath sounds on auscultation Fiberoptic bronchoscopic confirmation of tracheal placement Sustained end-tidal CO₂ waveform (EtCO₂ >15 mmHg for ≥3 breaths)

Secondary outcomes

  1. Time to intubation

    Time frame: Perioperative

    from laryngoscopy start to confirmation (seconds)

  2. Intubation recall

    Time frame: From drug injection to Remove the endotracheal tube

  3. Changes in SBP

    Time frame: Perioperative

    ΔSBP, :SBPₜ₀ - SBPₜ₁ ; (SBPₜ₀ - SBPₜ₁)/SBPₜ₀ × 100%

  4. Changes in HR

    Time frame: Perioperative

    ΔHR (absolute and percentage change):HRₜ₀ - HRₜ₁ ; (HRₜ₀ - HRₜ₁)/HRₜ₀ × 100%

  5. Changes in SpO₂

    Time frame: Perioperative

    ΔSpO₂ (absolute and percentage change):SpO₂ₜ₀ - SpO₂ₜ₂ₘᵢₙ ; (SpO₂ₜ₀ - SpO₂ₜ₂ₘᵢₙ)/SpO₂ₜ₀ × 100%

Sponsors and collaborators

Lead sponsor

Zhongnan Hospital

Other

Registry information

Official study title

The Impact of Sequential Order of Emergency Sedation and Neuromuscular Blocking Agent During Rapid Sequence Induction on Tracheal Intubation

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Aug 3, 2026
Registry last updated
Aug 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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