Sequential Method Determination of Oxycodone for Thoracoscope Surgery Median Effective Dose of Acute Pain Treatment

The goal of this clinical trial is to measure the median effective dose of oxycodone for the treatment of acute pain after thoracoscopic lobectomy. This clinical trial was divided into two groups based on age, Group I (Age < 65 years old) and Group II (Age ≥65 years old). We used the sequential allocation designed by Dixon. The initial oxycodone dose was set to 0.1 mg/kg.A satisfactory or an unsatisfactory analgesic response of the previous patient determined, respectively, the relative 10% decrease or increase in the dose of oxycodone the next patient received in the same group. The patient before the first crossover point was included as the first case for ED50 estimation in each group.The study was conducted until 7 crossover points were collected

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Key information

Conditions

Oxycodone Acute Postoperative Pain Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms Thoracoscopic Lobectomy

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

The first unilateral thoracoscopic lobectomy was performed under general anesthesia
age 18- 80 years old
American Society of Anesthesiologists (ASA) physical status I-III
Sign the informed consent of the patients

Exclusion criteria

Moderate to severe obesity (i.e., BMI > 30kg/m2)
Allergic or hypersensitive reaction to oxycodon
A history of chronic pain
Patients with significant heart, pulmonary, liver or renal disease

Treatment and study plan

Oxycodone will be administered intravenously in the group 1

Drug

Oxycodone will be administered intravenously 30min before the end of surgery, and Dixon sequential method will be used for the study

Other names: They are grouped according to age

Primary outcomes

The median effective dose

Time frame: 3 minutes after remoal of the endotracheal tube, 30minutes after remoal of the endotracheal tube

The median effective dose of oxycodone for the treatment of acute pain after thoracoscopic lobectomy

Study contacts

Contact information is provided by the study sponsor or research team.

Wu Jian bo, doctorate

CONTACT

[email protected]

18560083793

Zhang min, master

CONTACT

[email protected]

18364183909

Sponsors and collaborators

Lead sponsor

Jianbo Wu

Other

Registry information

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2026
First posted: Aug 2, 2024
Registry last updated: Aug 2, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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