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Completed

NCT Number: NCT00772096

Septic Encephalopathy and Late Cognitive Dysfunction

Delirium and long-term cognitive dysfunction are important problems in intensive care patients. Patients with sepsis are at a high risk of developing delirium (septic encephalopathy), which may be an important risk factor for the development of long-term cognitive dysfunction.

Working hypotheses: 1. Septic encephalopathy and cognitive dysfunction are caused by an unspecific reaction of the brain to an intense inflammatory stimulus. 2. It is possible to therapeutically influence the inflammatory response and its effects on the brain.

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Key information

Conditions

Sepsis Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Severe Sepsis Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

University Hospital Basel

Basel, 4031, Switzerland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Admitted to an intensive care unit for treatment of sepsis, severe sepsis or septic shock
  • Age 18 or older

Exclusion criteria

  • Primary infection of the CNS
  • History of cerebrovascular disease
  • History of any neoplasia involving the CNS
  • History of long-term psychiatric medication
  • History of allergy to fish- or egg-protein
  • Severe coagulation abnormalities
  • Clinical signs of altered coagulation, active bleeding
  • Pregnancy

Treatment and study plan

n-3 fatty acids

Drug

Sponsors and collaborators

Lead sponsor

University Hospital, Basel, Switzerland

Other

Registry information

Official study title

Septic Encephalopathy and Late Cognitive Dysfunction in Patients With Sepsis - the Role of Inflammation

Important dates

Study start
2008
Primary completion
2011
Study completion
2011
First posted
Oct 15, 2008
Registry last updated
Mar 10, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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