Sentinel Lymph Node Biopsy Using Peritumoral Injection With Blue Dye Confirmation

Using a technique combining Technetium-99 sulfur colloid and Lymphazurin Blue Dye, we have established that the sentinel node predicts the pathology results of the rest of the axillary lymph nodes. This minimally invasive technique, which can be readily performed under local anesthesia, makes the need for full axillary lymph node dissection unnecessary for most patients. If the sentinel node is negative, no further surgery is necessary. If positive, a complete axillary node dissection is performed. In addition, the injections are made while the patient is under anesthesia, reducing the physical and psychological pain that accompanies injections done pre-operatively.

Inclusion criteria

• Breast cancer requiring lymph node evaluation
• Clinically negative lymph nodes in the axilla
• Willing participation following an informed consent process

Exclusion criteria

• Patients with clinically positive lymph nodes
• Pregnancy (if a pregnant female should be diagnosed with breast cancer an exception would be considered on a case to case basis)
• Previous axillary lymphadenectomy