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NCT Number: NCT06548113

Sensory Synchronized Imaging and Neuromodulation

The purpose of this research study is to better understand the relationship between the type of brain stimulation used and how it changes brain activity in adult military Veterans. The goal is to use this understanding to develop new, personalized brain stimulation. The investigators evaluate brain changes from different types of transcranial magnetic brain stimulation (TMS).

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Key information

Conditions

Major Depressive Disorder Depressive Disorder Depressive Disorder, Major Mental Disorders Mood Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

VA Palo Alto Health Care System, Palo Alto, CA

Palo Alto, California, 94304-1207, United States

Location contact

Jessica M Ross, PhD

CONTACT

[email protected]

(530) 902-2450

Jessica M Ross, PhD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men and women, ages 18 years and up
  • English speaking
  • Military Veterans

Exclusion criteria

  • Those with a contraindication for MRIs (e.g. implanted metal)
  • History of head trauma with loss of consciousness
  • History of seizures or on medications that substantially reduce seizure threshold
  • Neurological or uncontrolled medical disease
  • Active substance abuse
  • Currently pregnant or breastfeeding

Treatment and study plan

TMS

Device

transcranial magnetic brain stimulation

Primary outcomes

  1. Transcranial Magnetic Stimulation (TMS) / Electroencephalography (EEG) change

    Time frame: 45 minutes

    Change in the TMS-EEG measure will be assessed before, during, and after each TMS session. Specifically, the difference in size of the evoked response after a single TMS pulse in the frontoparietal region will be quantified in microVolts and compared between standard TMS and sensory-entrained TMS (se-TMS).

Study contacts

Contact information is provided by the study sponsor or research team.

Jessica M Ross, PhD

CONTACT

[email protected]

(530) 902-2450

Sponsors and collaborators

Lead sponsor

VA Office of Research and Development

Fed

Collaborators

  • National Institute of Mental Health (NIMH)
  • Stanford University

Registry information

Official study title

Investigation of Sensory Synchronized Human Brain Imaging and Neuromodulation

Important dates

Study start
2026
Primary completion
2030
Study completion
2030
First posted
Aug 12, 2024
Registry last updated
Jun 25, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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