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NCT Number: NCT07598695

Sensory Feedback and Hand Motor Adaptation

The following experiment will be conducted with 15 chronic stroke survivors and 15 control subjects. Subjects will perform hand movements in the virtual reality environment using a head-mounted display. Quest's onboard cameras allow real-time tracking of hand motion, estimating joint angles of the finger and the thumb. For each feedback manipulation condition (i.e., movement amplification or reduction), the estimated joint angles will be multiplied by a factor greater than 1 (amplification) or a factor smaller than 1 (reduction). Then the newly-estimated hand posture will be displayed in the VR environment. Subjects will be randomly assigned into two groups (A and B), who will receive the assistance in a different order. Subjects will perform finger extension under three conditions: no sensory modulation, movement visual feedback (VF) amplification, and movement VF reduction (error augmentation), while their movement muscle activation patterns are recorded.

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Key information

Age range

20 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

Catholic University of America

Washington D.C., District of Columbia, 20064, United States

Location status: Recruiting

Location contact

Sang Wook Lee, PhD

CONTACT

[email protected]

312-608-8001

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

for stroke group:

  • Age: 20 - 70 years old
  • First-ever unilateral cortical stroke with resultant hemiparesis at least 6 months prior to the experimental testing
  • Fugl-Meyer Upper Extremity Section 31 - 55

Exclusion criteria

for both groups:

  • Presence of concurrent severe medical illness
  • Pain in hand or arm with movements
  • Loss of voluntary control of fingers and thumb
  • Inability to provide informed consent
  • Musculoskeletal injuries (e.g., fracture) or medical complications (e.g., severe cardiovascular disease).

Treatment and study plan

Visual ROM augmentation

Device

Finger joint ROM is amplified.

Visual ROM reduction

Device

Visual feedback of finger joint ROM is reduced.

Primary outcomes

  1. Joint range of motion (ROM)

    Time frame: Periprocedural

    range of motion of individual finger joints under each condition, measured by embedded cameras that digitize individual finger segments

Secondary outcomes

  1. Muscle activation

    Time frame: Periprocedural

    Activation level of hand muscles will be measured using surface EMG electrodes attached to the major hand muscles including extensor digitorum communis, flexor digitorum superficialis, and first dorsal interosseous.

Study contacts

Contact information is provided by the study sponsor or research team.

Sang Wook Lee, PhD

CONTACT

[email protected]

202-319-6218

Sponsors and collaborators

Lead sponsor

The Catholic University of America

Other

Collaborators

  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Registry information

Official study title

Impact of Altered Sensory Feedback on Adaptation of Hand Muscle Coordination of Stroke Survivors

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
May 20, 2026
Registry last updated
May 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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