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OpenTrials
Completed

NCT Number: NCT00115102

Sensory Examination and Pharmacological Modulation of Oral Hyperexcitability in Patients With Atypical Odontalgia and Matched Healthy Controls

This project examines experimental pain and chronic pain in the mouth, specifically the condition called atypical odontalgia (AO:atypical toothpain). In 16 patients with AO and 16 healthy persons, capsaicin (chili-pepper) is applied to the gingiva to cause pain. This pain is evaluated by the participants. In three sessions, 3 different medications are tested for effect on the pain. The medications are fentanyl, S-ketamine and placebo-treatment (saline). The aim is to know more about pain mechanisms in AO in order to develop an effective treatment.

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Key information

Conditions

Odontalgia Facial Pain Nervous System Diseases Neuralgia Neurologic Manifestations Neuromuscular Diseases Pain Pathological Conditions, Signs and Symptoms Peripheral Nervous System Diseases Signs and Symptoms Stomatognathic Diseases Tooth Diseases Toothache

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Danish Pain Research Center

Aarhus, DK-8000, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Atypical odontalgia

Exclusion criteria

  • BMI > 30
  • Heart conditions
  • Lung disease
  • Diseases of the liver or kidneys
  • Hypertension, untreated

Treatment and study plan

Fentanyl

Drug

S-ketamine

Drug

Primary outcomes

  1. Pain

  2. Sensitivity to heat and cold

  3. Sensitivity to mechanical stimuli

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Collaborators

  • Danish Pain Research Center

Registry information

Important dates

Study start
2004
Study completion
2005
First posted
Jun 21, 2005
Registry last updated
Jun 20, 2006

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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