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NCT Number: NCT03286686

Sensori-motor and Perceptual Functions of the PPC.

To produce hand's movement directed towards a target, the investigator must combine several sensory information, such as vision or proprioception. The posterior parietal cortex (PPC) is a region of the cortex involved in this multisensory integration. A lesion of the PPC cause a visuo-motor trouble called optic ataxia but these patients also have perceptual troubles.

The aim of the study is to understand the different functions of the PPC and especially how the processes of spatial coding of the sensory information influences perception and motor planning.

In this study, the investigator want to explore the sensory motor and the perceptual performance of patients with optic ataxia compared with healthy subjects, using 6 behavioral tests.

Objectify the consequences of PPC impairment (visual-motor and perceptual consequences) on patients' quality of life and autonomy.

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Key information

Conditions

Healthy Volunteers Optic Ataxia

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

U1028 INSERM - CNRS UMR 5292 Equipe ImpAct

Bron, 69500, France

Location status: Recruiting

Location contact

Laure Pisella, PhD

CONTACT

[email protected]

4 72 91 34 05 ext. +33

Laure Pisella, PhD

PRINCIPAL_INVESTIGATOR

Sophie JACQUIN-COURTOIS, MD

SUB_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

All patients and healthy subjects:

  • male and female, age from 18 to 75 years included
  • normal vision or corrected vision
  • covered by social security
  • signed written informed consent

Patients:

  • neurological injury in posterior parietal cortex supported by a cerebral MRI
  • present optic ataxia symptoms Healthy subjects
  • no known neurological injury

Exclusion criteria

  • unable to comply with the tasks (neurological, psychiatric, sensory or motor troubles)

Treatment and study plan

point targets

Behavioral

In the experiences 1 and 2, the participant needs to point different visual targets (LED) in the dark.

Tactile stimulation

Behavioral

In the experience 3, a tactile stimulation is applied to the middle finger of the 2 hands. The participant needs to indicate into a microphone when he feels the stimulation.

visual images

Behavioral

Target dots or visual images are presented on a computer screen. The participant is required to point to the targets or to react as soon as possible by pressing a response button when they are detected.

Primary outcomes

  1. response error - number of pointing error

    Time frame: Day 0 after each stimulation

  2. response error -measure of reaction times

    Time frame: Day 0 after each stimulation

  3. response error - percentage of right responses

    Time frame: Day 0 after each stimulation

Study contacts

Contact information is provided by the study sponsor or research team.

Laure PISELLA, PhD

CONTACT

[email protected]

4 72 91 34 05 ext. +33

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Official study title

Sensori-motor and Perceptual Functions of the Posterior Parietal Cortex (PPC) in Patients With Optic Ataxia (AO) and Healthy Subjects.

Acronym: PPCfonctions

Important dates

Study start
2018
Primary completion
2031
Study completion
2031
First posted
Sep 18, 2017
Registry last updated
Jan 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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