Sensitivity to Ovarian Hormones and Depression in Adolescents

The goal of this observational study is to learn about the relationship between changes in ovarian hormones (estrogen and progesterone) and adolescent depression. The main question it aims to answer is:

Can we identify a subset adolescents assigned female at birth with a history of depression who are particularly sensitive to changes in ovarian hormones? Participants will be monitoring daily absolute ovarian hormone levels at home using the Mira Analyzer and answer online survey questions about their mental health for 90 days.

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Key information

Conditions

Depressed Behavior Behavioral Symptoms Consciousness Disorders Depression Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

12 year–18 year

Sex eligibility

Female

Study type

Observational

Primary location

University of Calgary

Calgary, Alberta, T2N1N4, Canada

Location contact

Whitney Hindmarch

CONTACT

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Assigned female at birth, at least 1 year post-menarche, naturally cycling, history of depression or symptoms of depression, and able to read and write in English.

Exclusion criteria

Pregnant or taking any hormonal or cycle altering medications/devices.

Treatment and study plan

Primary outcomes

Identification ovarian hormone affect sensitivity

Time frame: 90 days

Identify depressed adolescents assigned female at birth with depressed affect sensitivity to changes in ovarian hormones across the menstrual cycle.

Study contacts

Contact information is provided by the study sponsor or research team.

Whitney Hindmarch, PhD

CONTACT

[email protected]

587-534-7260

Sponsors and collaborators

Lead sponsor

University of Calgary

Other

Registry information

Acronym: SOHDA

Important dates

Study start: 2026
Primary completion: 2027
Study completion: 2027
First posted: Jan 5, 2026
Registry last updated: Jan 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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