Skip to main content
OpenTrials
Not Yet Recruiting

NCT Number: NCT07461272

Self-hangIng Patient and Hyperbaric Oxygen Therapy _ SIPHON Study

During an attempted hanging, patients present severe neurological distress that can lead to major neuropsychiatric sequelae. These sequelae are notably due to significant cerebral edema related to hanging. Hyperbaric Oxygen therapy is known to reduce cerebral edema and improve cerebral perfusion. The main objective of the study is to evaluate in patients who have attempted hanging without presenting cardio-respiratory arrest, the effect of one Hyperbaric Oxygen therapy session in addition to standard intensive care management on a potential reduction in short-term neurological sequelae. Patients will benefit from either standard management or standard management associated with one Hyperbaric Oxygen therapy session

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Conditions

Suicide Behavior Behavioral Symptoms Self-Injurious Behavior

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients who present, following an attempted hanging, neurological distress defined by the presence of one or more of the following criteria:

  • Glasgow score < 13/15
  • Confusional syndrome
  • Psychomotor agitation Who most of the time require optimal neuroprotection by sedation and invasive mechanical ventilation for the purpose of protecting the airways.
  • Patient aged over 18 years,
  • Suicide attempt by hanging without cardiocirculatory arrest,
  • Patient insured socially and able to understand the information provided

Exclusion criteria

  • Response time exceeded by > 6 hours from the hanging
  • Attempted hanging with immediate return to normal consciousness
  • Refusal of consent from the family or trusted person at the time of inclusion in the study,
  • Patients and/or families unable to understand the information provided

Treatment and study plan

OXYGENE MEDICINAL LIQUIDE AIR PRODUCTS MEDICAL

Drug

In addition to standard intensive care management, patients will receive a hyperbaric oxygen therapy session within eight hours of admission to intensive care (the hyperbaric oxygen therapy session lasts two hours and must be completed eight hours after the hanging attempt).

Primary outcomes

  1. Montreal Cognitive Assessment Score

    Time frame: 72 hours plus or minus 6 hours

    The score can be interpreted as follows:

    ≥ 26/30 = no neurocognitive impairment 18-25/30 = mild impairment 10-17 = moderate impairment Less than 10 = severe impairment

Secondary outcomes

  1. Montreal Cognitive Assessment Score

    Time frame: Montreal Cognitive Assessment Score at 6 months

    The score can be interpreted as follows:

    ≥ 26/30 = no neurocognitive impairment 18-25/30 = mild impairment 10-17 = moderate impairment Less than 10 = severe impairment

  2. Duration of mechanical ventilation

    Time frame: Participants will be monitored for duration of mechanical ventilation Participants will be monitored for duration of mechanical ventilation, an expected average of 24 hours

  3. Duration of hospital stay

    Time frame: Participants will be monitored for duration of hospital stay, an expected average of 4 days.

  4. Number of adverse events

    Time frame: Number of adverse effects during hospitalization, an expected average of 4 days.

Sponsors and collaborators

Lead sponsor

University Hospital, Lille

Other

Registry information

Official study title

Self-hangIng Patient and Hyperbaric Oxygen Therapy - SIPHON Study / Place de l'Oxygénothérapie Hyperbare Dans la Prise en Charge Des Tentatives de Pendaison

Acronym: SIPHON

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Mar 10, 2026
Registry last updated
May 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.