NCT Number: NCT03804697
Asian populations have a lower rate of high-risk gene mutations of venous thrombosis, which means a reasonable perioperative anticoagulant management after hip or knee arthroplasty for Caucasian populations may be too excessive for Asians. So, individual patient risk assessment, rather than a "blanket policy", is considered the best thromboembolism prophylaxis for Asians.The purpose of this study was to evaluate the effectiveness and safety of selective thromboembolism prophylaxis compared with conventional thromboembolism prophylaxis by risk stratification with thromboelastography (TEG) after joint arthroplasty for Asian populations.
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Interventional
Not applicable
Asian patients who underwent hip or knee arthroplasty in Guangdong General Hospital from August 2016 to August 2017 were randomly divided into selective anticoagulation group (SAG) and conventional anticoagulation group (CAG). SAG used anticoagulant when TEG indicated hypercoagulability while CAP used anticoagulant until one month after surgery regularly. Data including patients' basic information, postoperative complications, perioperative clotting index, intraoperative blood loss, perioperative TEG, volume of drainage, and blood transfusion were evaluated.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Selective anticoagulation group used anticoagulant once thromboelastography indicated hypercoagulable state. Conventional anticoagulation group used anticoagulant until one month after surgery routinely. The main difference was that the experimental group did not use anticoagulation if the thromboelastography indicated that the blood coagulation status was normal while the control group use anticoagulation routinely.
Other names: Thromboelastography
Time frame: 1 day after surgery
Measured by ultrasound,
Time frame: 3 days after surgery
Measured by ultrasound
Time frame: 5 days after surgery
Measured by ultrasound
Time frame: 1 month after surgery
Measured by ultrasound
Time frame: 3 months after surgery
Measured by ultrasound
Time frame: 6 months after surgery
Measured by ultrasound
Time frame: 1 day before surgery
Measured by Complete Blood Count
Time frame: 1 day after surgery
Measured by Complete Blood Count
Time frame: 3 days after surgery
Measured by Complete Blood Count
Time frame: 5 days after surgery
Measured by Complete Blood Count
Time frame: 1 day before surgery
Number of Hemoglobin Measured by Blood Test
Time frame: 1 day after surgery
Number of Hemoglobin Measured by Blood Test
Time frame: 3 days after surgery
Number of Hemoglobin Measured by Blood Test
Time frame: 5 days after surgery
Number of Hemoglobin Measured by Blood Test
Time frame: 1 day before surgery
Number of Red Blood Cell Measured by Complete Blood Count
Time frame: 1 day after surgery
Number of Red Blood Cell Measured by Complete Blood Count
Time frame: 3 days after surgery
Number of Red Blood Cell Measured by Complete Blood Count
Time frame: 5 days after surgery
Number of Red Blood Cell Measured by Complete Blood Count
Time frame: During Hospitalization
Volume of Blood Transfusion
Time frame: During Hospitalization
Number of patients who receive transfusion divided by total number of patients in the group
Time frame: During Hospitalization
Number of patients who suffer superficial infection
Time frame: 1 month after surgery
Number of patients who suffer superficial infection
Time frame: 3 months after surgery
Number of patients who suffer superficial infection
Time frame: 6 months after surgery
Number of patients who suffer superficial infection
Time frame: During Hospitalization
Number of patients who suffer deep infection
Time frame: 1 month after surgery
Number of patients who suffer deep infection
Time frame: 3 months after surgery
Number of patients who suffer deep infection
Time frame: 6 months after surgery
Number of patients who suffer deep infection
Time frame: 1 month after surgery
Number of patients who suffer ecchymosis divided by total number of patients in the group
Guangdong Provincial People's Hospital
Other
Selective Thromboembolism Prophylaxis After Total Hip Arthroplasty or Total Knee Arthroplasty by a Risk Stratification With Thromboelastography for Asian Populations: A Randomized Control Trial
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