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Completed

NCT Number: NCT02219295

SEGATROM: Sensory and Gastrointestinal Impact of Taste Receptor Variants on Human Metabolism and Nutrition

We investigate the impact of taste receptors (sweet, bitter and umami) on human metabolism. There ist growing evidence, that components of the taste signalling system, including the taste receptor proteins , have important functions in the regulation of metabolic parameters in non-gustatory tissues.

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Key information

Conditions

Disorder of Glucose Regulation

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Clinical Nutrition

Bergholz-Rehbrücke, Brandenburg, D-14558, Germany

About this study

We apply different sweet, bitter and umami taste compounds in a single dose in the human intervention. We use substances as for instance glucose, sucrose,saccharin and lactisol in the sweet part, and substances from cabbage, beer or red endive in the bitter part. For umami we take glutamate.

Blood samples are collected at baseline and 6 times thereafter up to 3hours, to analyse the incretins GLP-1(glucagon-like peptide 1) and GIP(gastrointestinal polypeptide) and other peptide hormones as insulin and PYY(peptide tyrosin trosin) in human beings.

Gastrointestinal mucosa is taken by gastroscopy from the lower duodenum from study subjects for analysis for the presence or absence of functional taste receptors in gastrointestinal tissues.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy persons

Exclusion criteria

  • Tumor in history
  • Pregnancy
  • Severe illness in history
  • Bodymass index below 18

Treatment and study plan

sweet block

Dietary Supplement

oral application of the above mentioned substances in 300 ml tap water in 5 min. , collection of blood at 0,15,30, 60 ,120,180 minutes for measurement of incretins GIP(gastrointestinal polypeptide) and GLP-1 (glucagon like peptide 1), Protein hormones PYY(Peptide YY),CCK (cholecystokinin), Leptin and Insulin

Other names: Sugars as sucrose, glucose, palatinose, galactose, artificial sweeteners as saccharin, sweet taste antagonist as lactisol

bitter block

Dietary Supplement

oral application of the above mentioned substances in 300 ml tap water, collection of blood samples at -15,0,15,30,60,120,180 min for Insulin, GIP,GLP-1, PYY and glucose

Other names: application of, sinigrin, lactucopicrin, iso-alpha-acid

umami-block

Dietary Supplement

oral application of umami substances as glutamate with and without IMP, collection of blood samples as above

Other names: application of glutamate and glutamate+IMP,

Gastroscopy

Other

gastroscopy with and without oral application of saccharin, tissue samples from th upper duodenum by endoscopy for the detection of taste receptor cells in the upper bowel

Other names: tissue samples, sweet taste receptor stimualtion, artificial sweetener saccharin, SGLT-1

Primary outcomes

  1. Area under the curve (AUC): changes of expression levels of the sweet , bitter und umami taste receptors in humans in the upper bowel and responses of incretins to receptor agonists and antagonists

    Time frame: three years

    measurement of incretins (GIP, GLP-1) and peptide hormones in human plasma after consumption of different sugars , sweeteners , bitter tasting ingredients of vegetables und umami. Measurement of expression levels in human intestinal mucosa before and after receptor stimulation

Secondary outcomes

  1. changes in the signalling cascade of the sweet receptor SGLT1 (sodium tranporter 1), changes of receptor expression

    Time frame: 3 years

    oral application of sweet tasting substances and antagonists, endoscopic collection of tissue samples, determination of molecular resonses by qRT-PCR and immunohistochemistry

Other outcomes

  1. Changes in the Area under the Curve (AUC) for PYY in different bitter tasting substances

    Time frame: 3 years

    oral application of sinigrin, lactucopicrin and other extracts of vegetables and umami, getting insight into the different bitter receptors

Sponsors and collaborators

Lead sponsor

German Institute of Human Nutrition

Other

Collaborators

  • Technical University of Munich

Registry information

Official study title

Sensory and Gastrointestinal Impact of Taste Receptor Variants on Human Metabolism and Nutrition

Acronym: SEGATROM

Important dates

Study start
2011
Primary completion
2014
Study completion
2014
First posted
Aug 18, 2014
Registry last updated
Jun 24, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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