Secondhand Smoking in Asthmatic Children

This study will investigate the interaction between GSTP1 / TNFa polymorphisms and passive smoking in children with asthma/wheezing. Contemporary second hand-smoke exposure will be confirmed by laboratory testing.

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Key information

Conditions

Asthma in Children Asthma Bronchial Diseases Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Pathological Conditions, Signs and Symptoms Respiratory Hypersensitivity Respiratory Sounds Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory Wheezing

Age range

12 month–18 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Subjects 1-18 years old with doctor diagnosed asthma/wheezing

Exclusion criteria

Premature birth (< 36 gestation weeks)
Asthma-like symptoms due to other conditions (infectious, congenital, mechanical)

Treatment and study plan

Lung function

Diagnostic Test

Spirometry test

White blood cell DNA extraction

Diagnostic Test

GSTP1 and TNFa polymorphisms with PCR

Urinary testing

Diagnostic Test

Urinary nicotine and cotinine detection

Primary outcomes

GSTP1 and TNFa variants in children with asthma

Time frame: 0 days

Sponsors and collaborators

Lead sponsor

AHEPA University Hospital

Other

Registry information

Official study title

Association Between Maternal Smoking and GSTP1 and TNFa Polymorphism in Children With Asthma/Wheezing

Important dates

Study start: 2010
Primary completion: 2015
Study completion: 2015
First posted: Apr 4, 2017
Registry last updated: Apr 11, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed