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Completed

NCT Number: NCT02572362

Secondary Cancer Risk After Radiation Therapy for Rectal Cancer

Retrospective study comparing dose distribution of 3D conformal radiotherapy (3DCRT) and volumetric-modulated arc therapy (VMAT) to estimate secondary cancer risk for patients having had radiation therapy for rectal cancer. Twenty-five patients are included in this study. Planning CT scans are used for comparison of dose distribution and calculation of second cancer risk.

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Key information

Conditions

Neoplasms, Second Primary Neoplasms

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Klinik Hirslanden, Institute for Radiotherapy

Zurich, CH-8032, Switzerland

About this study

A model-based Analysis calculating the organ-specific excess lifetime attributable risk using the planning CT data sets of 25 patients to estimate second cancer risk for patients after radiotherapy for rectal cancer comparing conventional 3DCRT with VAMT techniques.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male/Female > 18 years of age
  • pre or postoperative radiation therapy for rectal cancer
  • Planning CT

Exclusion criteria

  • Planning CT not available

Treatment and study plan

No intervention in this retrospective study

Other

No Intervention in this retrospective Analysis. All patients included did receive Radiation therapy Independent of this study

Primary outcomes

  1. Calculation of the organ-specific excess lifetime attributable risk (LAR) (%)

    Time frame: 60 years (model-based calculation)

    LAR is calculated for variable Ages at exposure

Sponsors and collaborators

Lead sponsor

Kantonsspital Graubuenden

Other

Collaborators

  • Klinik Hirslanden, Zurich

Registry information

Official study title

Estimation of Second Cancer Risk in Patients Planned With Different Radiotherapy Regimes for Rectal Cancer - A Planning Study and Model-based Analysis

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Oct 8, 2015
Registry last updated
Dec 13, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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